Purinergic System and Cervical Cancer: Perspectives

62 We have recently published an article entitled “Purinergic signaling and tumor microenvironment in cervical Cancer” [1]. In this paper, we reviewed the last studies about purinergic signaling and cervical cancer, highlighting the intrinsic factors related to the inflammatory process, such as extracellular nucleotides and adenosine components of the purinergic system. Our review focused on the role of the purinergic system in cervical cancer, especially regarding the interaction of extracellular nucleotides with their respective receptors expressed in the tumor microenvironment of cervical cancer and their role in the host immune response. Here we comment the main points of our work and suggest further basic and clinical investigations related to these key factors.