苯并咪唑候选物现代合成方法的关键分析

IF 0.9 Q4 CHEMISTRY, PHYSICAL Current Organocatalysis Pub Date : 2023-03-29 DOI:10.2174/2213337210666230329103657
Shikha Sharma, Neha Dangi, Nittin Mittal, Naresh Kalra
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引用次数: 0

摘要

背景:苯并咪唑是一种显著的杂环化合物,其中苯基环与咪唑环在4和5位融合。苯并咪唑衍生物在制药工业中具有广泛的药用活性。因此,苯并咪唑衍生物的合成在这一科学领域具有挑战性。方法:在苯并咪唑的合成中,已有羰基化合物与邻苯二胺的简单亲核取代和缩合反应。目前,绿色化学方面,如无溶剂条件,无金属条件,或使用纳米颗粒催化剂以各种方式涉及缩合和环化是新时代的方法。结果:绿色化学方法广泛应用于各种化学反应中,如观察到使用无溶剂条件、无金属条件或使用纳米颗粒催化剂分子是合成苯并咪唑衍生物更有效的方法。结论:在本综述中,涵盖了直到2021年底才在文献中描述的苯并咪唑支架合成。单取代苯并咪唑(MSBs)和双取代苯并咪唑(DSBs)是目前我们研究的主要对象。人们发现了不同的方法来制备苯并咪唑的功能化衍生物,这是一种强有力的支架。
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A Critical Analysis of the Modern Synthetic Procedures Used to Produce Benzimidazole Candidates
Background: Benzimidazole is a remarkable heterocyclic chemical compound in which the phenyl ring is fused with the imidazole ring at positions 4 and 5. Benzimidazole derivatives have lots of medicinal activity in the pharmaceutical industry. Therefore, the synthesis of benzimidazole derivatives is challenging in this scientific field. Methods: In benzimidazole synthesis, simple nucleophilic substitution and condensation reactions involving carbonyl compounds and o-phenylenediamine have been used in previous times. Currently, green chemistry aspects such as solvent-free conditions, metal-free conditions, or using nanoparticle catalysts in various ways involving condensation, and cyclization are the methods of the new era. Results: Green chemistry methods are used widely in various chemical reactions, such as it was observed that the use of solvent-free conditions, metal-free conditions, or using nanoparticle catalysts molecules is a more efficient way to synthesize benzimidazole derivative. Conclusion: In this review, benzimidazole scaffold syntheses that have only recently been described in the literature through the end of 2021 are covered. Monosubstituted benzimidazoles (MSBs) and disubstituted-benzimidazoles (DSBs) are the primary targets of our research currently. Different ways have been found to make functionalized derivatives of benzimidazole, which are shown in this review as a powerful scaffold.
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来源期刊
Current Organocatalysis
Current Organocatalysis CHEMISTRY, PHYSICAL-
CiteScore
2.00
自引率
0.00%
发文量
28
期刊介绍: Current Organocatalysis is an international peer-reviewed journal that publishes significant research in all areas of organocatalysis. The journal covers organo homogeneous/heterogeneous catalysis, innovative mechanistic studies and kinetics of organocatalytic processes focusing on practical, theoretical and computational aspects. It also includes potential applications of organocatalysts in the fields of drug discovery, synthesis of novel molecules, synthetic method development, green chemistry and chemoenzymatic reactions. This journal also accepts papers on methods, reagents, and mechanism of a synthetic process and technology pertaining to chemistry. Moreover, this journal features full-length/mini review articles within organocatalysis and synthetic chemistry. It is the premier source of organocatalysis and synthetic methods related information for chemists, biologists and engineers pursuing research in industry and academia.
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