N. Huda, H. Ghneim, Fozia Fozia, Mushtaq Ahmed, N. Mushtaq, N. Sher, Rahmattualh Khan, Ijaz Ahmad, Y. Al-Sheikh, J. Giesy, M. A. Aboul-Soud
{"title":"Kickxia elatine诱导的银纳米粒子的绿色合成及其抗乙酰胆碱酯酶作用","authors":"N. Huda, H. Ghneim, Fozia Fozia, Mushtaq Ahmed, N. Mushtaq, N. Sher, Rahmattualh Khan, Ijaz Ahmad, Y. Al-Sheikh, J. Giesy, M. A. Aboul-Soud","doi":"10.1515/gps-2023-0060","DOIUrl":null,"url":null,"abstract":"Abstract The synthesis of silver nanoparticles (AgNPs) by the green method is favored as compared to chemical synthesis due to their appreciable properties of less toxicity and simple synthesis. The current study designed the biosynthesis of AgNPs in one step by using the plant Kickxia elatine (KE) extract and then investigated its inhibiting activity against rat’s brain acetylcholinesterase (AChE) ex vivo. Ultraviolet spectrum at 416 nm confirmed the formation of AgNPs. X-ray diffractometer calculated size was reported to be 42.47 nm. The SEM analysis confirmed spherical-shaped AgNPs. FT-IR suggested that the phytochemical groups present in the KE extract and their nanoparticles (NPs) are responsible for the biosynthesized of NPs. EDX analysis presented that Ag was the chief element with 61.67%. Both KE extract and AgNPs showed significant anti-AChE activity at 175 µg·mL−1. Statistical analysis showed that both KE and AgNPs exhibited non-competitive type inhibition against AChE, i.e. V max decreased (34.17–68.64% and 22.29–62.10%), while K m values remained constant. It is concluded that KE and AgNPs can be considered an inhibitor of rats’ brain AChE. Furthermore, the synthesis of AgNP-based drugs can be used as a cheaper and alternative option against diseases such as Alzheimer’s disease.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":null,"pages":null},"PeriodicalIF":3.8000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Green synthesis of Kickxia elatine-induced silver nanoparticles and their role as anti-acetylcholinesterase in the treatment of Alzheimer’s disease\",\"authors\":\"N. Huda, H. Ghneim, Fozia Fozia, Mushtaq Ahmed, N. Mushtaq, N. Sher, Rahmattualh Khan, Ijaz Ahmad, Y. Al-Sheikh, J. Giesy, M. A. Aboul-Soud\",\"doi\":\"10.1515/gps-2023-0060\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract The synthesis of silver nanoparticles (AgNPs) by the green method is favored as compared to chemical synthesis due to their appreciable properties of less toxicity and simple synthesis. The current study designed the biosynthesis of AgNPs in one step by using the plant Kickxia elatine (KE) extract and then investigated its inhibiting activity against rat’s brain acetylcholinesterase (AChE) ex vivo. Ultraviolet spectrum at 416 nm confirmed the formation of AgNPs. X-ray diffractometer calculated size was reported to be 42.47 nm. The SEM analysis confirmed spherical-shaped AgNPs. FT-IR suggested that the phytochemical groups present in the KE extract and their nanoparticles (NPs) are responsible for the biosynthesized of NPs. EDX analysis presented that Ag was the chief element with 61.67%. Both KE extract and AgNPs showed significant anti-AChE activity at 175 µg·mL−1. Statistical analysis showed that both KE and AgNPs exhibited non-competitive type inhibition against AChE, i.e. V max decreased (34.17–68.64% and 22.29–62.10%), while K m values remained constant. It is concluded that KE and AgNPs can be considered an inhibitor of rats’ brain AChE. Furthermore, the synthesis of AgNP-based drugs can be used as a cheaper and alternative option against diseases such as Alzheimer’s disease.\",\"PeriodicalId\":12758,\"journal\":{\"name\":\"Green Processing and Synthesis\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Green Processing and Synthesis\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1515/gps-2023-0060\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Green Processing and Synthesis","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1515/gps-2023-0060","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Green synthesis of Kickxia elatine-induced silver nanoparticles and their role as anti-acetylcholinesterase in the treatment of Alzheimer’s disease
Abstract The synthesis of silver nanoparticles (AgNPs) by the green method is favored as compared to chemical synthesis due to their appreciable properties of less toxicity and simple synthesis. The current study designed the biosynthesis of AgNPs in one step by using the plant Kickxia elatine (KE) extract and then investigated its inhibiting activity against rat’s brain acetylcholinesterase (AChE) ex vivo. Ultraviolet spectrum at 416 nm confirmed the formation of AgNPs. X-ray diffractometer calculated size was reported to be 42.47 nm. The SEM analysis confirmed spherical-shaped AgNPs. FT-IR suggested that the phytochemical groups present in the KE extract and their nanoparticles (NPs) are responsible for the biosynthesized of NPs. EDX analysis presented that Ag was the chief element with 61.67%. Both KE extract and AgNPs showed significant anti-AChE activity at 175 µg·mL−1. Statistical analysis showed that both KE and AgNPs exhibited non-competitive type inhibition against AChE, i.e. V max decreased (34.17–68.64% and 22.29–62.10%), while K m values remained constant. It is concluded that KE and AgNPs can be considered an inhibitor of rats’ brain AChE. Furthermore, the synthesis of AgNP-based drugs can be used as a cheaper and alternative option against diseases such as Alzheimer’s disease.
期刊介绍:
Green Processing and Synthesis is a bimonthly, peer-reviewed journal that provides up-to-date research both on fundamental as well as applied aspects of innovative green process development and chemical synthesis, giving an appropriate share to industrial views. The contributions are cutting edge, high-impact, authoritative, and provide both pros and cons of potential technologies. Green Processing and Synthesis provides a platform for scientists and engineers, especially chemists and chemical engineers, but is also open for interdisciplinary research from other areas such as physics, materials science, or catalysis.