单极和双极经尿道膀胱肿瘤切除术标本组织学变化(热伪影)的比较研究

Vasudevan Thirugnanasambandam, J. Ramanathan
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引用次数: 1

摘要

目的本研究的主要目的是研究膀胱肿瘤单极和双极经尿道切除术(TURBT)切除标本的组织学变化(热伪影)。患者和方法本研究于2012年3月至2013年2月进行。这是对单极和双极切除标本的组织学变化(热伪影)进行的比较研究。获得了机构伦理委员会的批准。所有患者均取得知情同意书。患者被随机分为两组,单极组或双极组,每组50人,接受TURBT。患者分别在甘氨酸和生理盐水中接受单极或双极TURBT。结果热伪影按世界卫生组织分级系统进行分级。在切除标本的组织病理学检查中没有发现任何困难。在单极组中,被检样品中有27(54%)处出现2级热损伤,17(34%)处出现1级热损伤。双极组受试者有07例(14%)2级热损伤,12例(24%)1级热损伤。结论双极能量切除标本的组织学切片的热损伤程度要小得多,而且级别的解释更容易,这是最重要的预后指标之一,尤其是在膀胱肿瘤中,因为高级别病变无疑会进展和复发。
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Comparative study of histological changes (thermal artefacts) in resected specimens of monopolar and bipolar trans-urethral resection of bladder tumours
Objective The primary aim of the study was to study the histological changes (Thermal artefacts) noted in the resected specimens between the Monopolar and Bipolar Trans-Urethral Resection of Bladder Tumours (TURBT). Patients and Methods The study was done between March 2012 and Feb 2013. This was a comparative study between Monopolar and Bipolar resection specimens studied for histological changes (Thermal artefacts). Institutional Ethics Committee approval was obtained. Informed consent was taken from all patients. Patients were randomized into two groups, Monopolar Group or Bipolar Group of 50 each to undergo TURBT. Patients either underwent Monopolar or Bipolar TURBT in Glycine and Saline respectively. Results Thermal artefacts were graded according to WHO (World Health Organization) grading system. There was no difficulty noticed during histo-pathological examination of resected specimens. In Monopolar group, there were 27 (54%) grade 2 thermal damage, 17 (34%) grade 1 thermal damage and no grade-3 thermal damage in examined specimen. In Bipolar group, there were 07 (14%) grade 2 thermal damage, 12 (24%) grade 1 thermal damage and no grade 3 thermal damage in examined specimen. Conclusion The degree of thermal damage is much lesser in histological sections of specimen resected using Bipolar energy and interpretation of the grade is easier which is one of the most important prognosticators especially in bladder tumours since high grade lesions are proven beyond doubt to progress and recur.
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