Symposium 4

The discovery of Autophagy-related genes (ATGs) by Dr. Yoshinori Ohsumi opened the door to solve the molecular mechanisms of autophagy. But, the research on autophagy does not still mature, rather it contains a large number of issues that should be addressed. To date, a series of ATG genes has been identified, but working mechanism of each ATG gene product remains unclear. Moreover, while growing lines of evidence shed light on the importance of unconventional mode of autophagy such as selective autophagy, the role in our life course is still a mystery. Further, while autophagy is considered to be involved in various vital events such as cellular differentiation, stem cell homeostasis and anti-aging, those regulatory mechanisms through autophagy are still not clear. In my talk, I show the role(s) of selective autophagy on transcriptional regulation and network. The 66th Annual Meeting of Japanese Association for Laboratory Animal Science