A. Alsahhaf, E. Alhamdan, Fahim Vohra, T. Abduljabbar, Ziaullah Chaudhry, Isaac Kuyunov
{"title":"新型生物标志物评价在种植体周围沟液作为种植体周围健康的疾病指标","authors":"A. Alsahhaf, E. Alhamdan, Fahim Vohra, T. Abduljabbar, Ziaullah Chaudhry, Isaac Kuyunov","doi":"10.1166/jbt.2023.3293","DOIUrl":null,"url":null,"abstract":"Objective: To assess various inflammatory biomarkers CCL-20, BAF, RANK-L, IL-23, and osteoprotegerin from PICF along with clinical parameters in participants with peri-implant mucositis and peri-implantitis. Material and Methods: Participants were gathered i.e., 30 with\n periimplantitis, 32 with peri-implant mucositis, and 32 healthy. Peri-implant parameters PIPD, BoP, and PIPI were measured in all participants. PICF samples were collected to assess the level of biomarkers CCL-20; BAF; IL-23; RANK-L, and OPG. For periodontal parameters, ranges and means were\n measured. Kruskal Wallis test was used for comparison between groups. For categorical data sets, the Pearson Chi-Square test was applied. The Bonferroni test was used for multiple comparisons. Results: Peri-implant parameter BoP in peri-implant mucositis and peri-implantitis was significantly\n higher compared to controls (p < 0.05). PIPD with healthy peri-implant conditions was, significantly less compared to peri-implantitis, and peri-implant mucositis (p<0.05). PIPI demonstrated no significant difference throughout different peri-implant conditions. CCL-20\n ng/mL in patients with peri-implant mucositis was found to be significantly higher (p < 0.05). BAF levels in peri-implantitis and peri-implant mucositis were comparable. The concentration of IL-23 ng/mL was found to be significantly lower in healthy controls (p < 0.05).\n Conclusion: Inflammatory biomarkers showed high levels of PICF in peri-implant disease patients compared to healthy controls. Individuals with peri-implant conditions experience the poor peri-implant probing depth and bleeding on probing.","PeriodicalId":15300,"journal":{"name":"Journal of Biomaterials and Tissue Engineering","volume":" ","pages":""},"PeriodicalIF":0.1000,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Novel Biomarker Evaluation in Peri-Implant Crevicular Fluid as Disease Indicators for Peri-Implant Health\",\"authors\":\"A. Alsahhaf, E. Alhamdan, Fahim Vohra, T. Abduljabbar, Ziaullah Chaudhry, Isaac Kuyunov\",\"doi\":\"10.1166/jbt.2023.3293\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: To assess various inflammatory biomarkers CCL-20, BAF, RANK-L, IL-23, and osteoprotegerin from PICF along with clinical parameters in participants with peri-implant mucositis and peri-implantitis. Material and Methods: Participants were gathered i.e., 30 with\\n periimplantitis, 32 with peri-implant mucositis, and 32 healthy. Peri-implant parameters PIPD, BoP, and PIPI were measured in all participants. PICF samples were collected to assess the level of biomarkers CCL-20; BAF; IL-23; RANK-L, and OPG. For periodontal parameters, ranges and means were\\n measured. Kruskal Wallis test was used for comparison between groups. For categorical data sets, the Pearson Chi-Square test was applied. The Bonferroni test was used for multiple comparisons. Results: Peri-implant parameter BoP in peri-implant mucositis and peri-implantitis was significantly\\n higher compared to controls (p < 0.05). PIPD with healthy peri-implant conditions was, significantly less compared to peri-implantitis, and peri-implant mucositis (p<0.05). PIPI demonstrated no significant difference throughout different peri-implant conditions. CCL-20\\n ng/mL in patients with peri-implant mucositis was found to be significantly higher (p < 0.05). BAF levels in peri-implantitis and peri-implant mucositis were comparable. The concentration of IL-23 ng/mL was found to be significantly lower in healthy controls (p < 0.05).\\n Conclusion: Inflammatory biomarkers showed high levels of PICF in peri-implant disease patients compared to healthy controls. Individuals with peri-implant conditions experience the poor peri-implant probing depth and bleeding on probing.\",\"PeriodicalId\":15300,\"journal\":{\"name\":\"Journal of Biomaterials and Tissue Engineering\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.1000,\"publicationDate\":\"2023-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Biomaterials and Tissue Engineering\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1166/jbt.2023.3293\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biomaterials and Tissue Engineering","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1166/jbt.2023.3293","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Novel Biomarker Evaluation in Peri-Implant Crevicular Fluid as Disease Indicators for Peri-Implant Health
Objective: To assess various inflammatory biomarkers CCL-20, BAF, RANK-L, IL-23, and osteoprotegerin from PICF along with clinical parameters in participants with peri-implant mucositis and peri-implantitis. Material and Methods: Participants were gathered i.e., 30 with
periimplantitis, 32 with peri-implant mucositis, and 32 healthy. Peri-implant parameters PIPD, BoP, and PIPI were measured in all participants. PICF samples were collected to assess the level of biomarkers CCL-20; BAF; IL-23; RANK-L, and OPG. For periodontal parameters, ranges and means were
measured. Kruskal Wallis test was used for comparison between groups. For categorical data sets, the Pearson Chi-Square test was applied. The Bonferroni test was used for multiple comparisons. Results: Peri-implant parameter BoP in peri-implant mucositis and peri-implantitis was significantly
higher compared to controls (p < 0.05). PIPD with healthy peri-implant conditions was, significantly less compared to peri-implantitis, and peri-implant mucositis (p<0.05). PIPI demonstrated no significant difference throughout different peri-implant conditions. CCL-20
ng/mL in patients with peri-implant mucositis was found to be significantly higher (p < 0.05). BAF levels in peri-implantitis and peri-implant mucositis were comparable. The concentration of IL-23 ng/mL was found to be significantly lower in healthy controls (p < 0.05).
Conclusion: Inflammatory biomarkers showed high levels of PICF in peri-implant disease patients compared to healthy controls. Individuals with peri-implant conditions experience the poor peri-implant probing depth and bleeding on probing.