{"title":"巴塞罗纳B期肝癌行肝切除术患者预后影响因素分析","authors":"Yonghan Zhang, Chi Zhang, Dexu Li","doi":"10.3760/CMA.J.CN113855-20191015-00599","DOIUrl":null,"url":null,"abstract":"Objective \nTo investigate the prognostic factors that influence Barcelona (Barcelona clinical liver cancer staging system, BCLC)stage B hepatocellular carcinoma patients after hepatectomy. \n \n \nMethods \nRetrospective analysis was made on clinical and pathological data of 50 standardized hemihepatectomy in Barcelona stage B hepatocellular carcinoma from 2013 to 2017. \n \n \nResults \nSingle-factor results showed that high expression of tumor microvascular invasion (MVI) and proliferation of nuclear antigen (Ki-67) were the prognostic factors ( respectively χ2 =8.411, 10.939, all P<0.05). Multivariate analysis showed that the difference of high expression of Ki-67 and survival rate was statistically significant (respectively F=5.710, 8.254, all P<0.05). Ki-67 expression level and tumor differentiation were statistically significant (χ2=0.497, P<0.05). There was a statistically significant difference in survival between the high-risk group and the low-risk group according to the risk factors (χ2=12.152, P<0.05). \n \n \nConclusions \nMVI and high expression of Ki-67 were high risk factors affecting the overall survival rate of liver cancer after hemihepatectomy. \n \n \nKey words: \nCarcinoma, hepatocellular; Hepatectomy; Prognosis","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prognostic influencing factors in patients of Barcelona stage B hepatocellular carcinoma undergoing hepatectomy\",\"authors\":\"Yonghan Zhang, Chi Zhang, Dexu Li\",\"doi\":\"10.3760/CMA.J.CN113855-20191015-00599\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo investigate the prognostic factors that influence Barcelona (Barcelona clinical liver cancer staging system, BCLC)stage B hepatocellular carcinoma patients after hepatectomy. \\n \\n \\nMethods \\nRetrospective analysis was made on clinical and pathological data of 50 standardized hemihepatectomy in Barcelona stage B hepatocellular carcinoma from 2013 to 2017. \\n \\n \\nResults \\nSingle-factor results showed that high expression of tumor microvascular invasion (MVI) and proliferation of nuclear antigen (Ki-67) were the prognostic factors ( respectively χ2 =8.411, 10.939, all P<0.05). Multivariate analysis showed that the difference of high expression of Ki-67 and survival rate was statistically significant (respectively F=5.710, 8.254, all P<0.05). Ki-67 expression level and tumor differentiation were statistically significant (χ2=0.497, P<0.05). There was a statistically significant difference in survival between the high-risk group and the low-risk group according to the risk factors (χ2=12.152, P<0.05). \\n \\n \\nConclusions \\nMVI and high expression of Ki-67 were high risk factors affecting the overall survival rate of liver cancer after hemihepatectomy. \\n \\n \\nKey words: \\nCarcinoma, hepatocellular; Hepatectomy; Prognosis\",\"PeriodicalId\":66425,\"journal\":{\"name\":\"中华普通外科杂志\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-03-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华普通外科杂志\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.CN113855-20191015-00599\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华普通外科杂志","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3760/CMA.J.CN113855-20191015-00599","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Prognostic influencing factors in patients of Barcelona stage B hepatocellular carcinoma undergoing hepatectomy
Objective
To investigate the prognostic factors that influence Barcelona (Barcelona clinical liver cancer staging system, BCLC)stage B hepatocellular carcinoma patients after hepatectomy.
Methods
Retrospective analysis was made on clinical and pathological data of 50 standardized hemihepatectomy in Barcelona stage B hepatocellular carcinoma from 2013 to 2017.
Results
Single-factor results showed that high expression of tumor microvascular invasion (MVI) and proliferation of nuclear antigen (Ki-67) were the prognostic factors ( respectively χ2 =8.411, 10.939, all P<0.05). Multivariate analysis showed that the difference of high expression of Ki-67 and survival rate was statistically significant (respectively F=5.710, 8.254, all P<0.05). Ki-67 expression level and tumor differentiation were statistically significant (χ2=0.497, P<0.05). There was a statistically significant difference in survival between the high-risk group and the low-risk group according to the risk factors (χ2=12.152, P<0.05).
Conclusions
MVI and high expression of Ki-67 were high risk factors affecting the overall survival rate of liver cancer after hemihepatectomy.
Key words:
Carcinoma, hepatocellular; Hepatectomy; Prognosis