肾脏疾病生物标志物与心房颤动的相关性:文献综述

Saira Rafaqat, Sana Rafaqat, Saima Sharif
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引用次数: 0

摘要

肾脏疾病和心房颤动经常同时发生。肾损伤增加了发生心房颤动(AF)的风险,并以双向方式与之相关,使其成为一种促血栓形成和促出血的疾病。在日本非瓣膜性房颤患者中,肌酐清除率较低与血栓栓塞、全因死亡和心血管死亡有关,但与大出血无关。血清胱抑素C水平升高的老年人AF患病率明显更高。成纤维细胞生长因子-23水平升高的中重度慢性肾脏病患者与流行性和偶发性AF独立相关。基线肾小球滤过率较高与AF风险增加相关。房颤患者胰岛素样生长因子结合蛋白-7水平升高,而循环组织金属蛋白酶抑制剂2水平降低也与房颤风险增加有关。房颤患者的非酯化脂肪酸和肝型脂肪酸结合蛋白水平较高。房颤患者血浆中白细胞介素-18水平也较高。此外,较高的基线尿素/血液尿素氮水平与女性房颤和男性和女性肾脏疾病的发生率显著相关。
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Association Between Biomarkers of Kidney Disorders and Atrial Fibrillation: A Literature Review
Kidney diseases and atrial fibrillation often occur together. Renal impairment increases the risk of developing incident atrial fibrillation (AF) and is linked to it in a bidirectional manner, making it a prothrombotic and pro-hemorrhagic condition. In Japanese patients with nonvalvular AF, lower creatinine clearance values were associated with thromboembolism, all-cause death, and cardiovascular death, but not with major haemorrhage. Older individuals with elevated serum levels of cystatin C had a significantly higher prevalence of AF. Moderate to severe chronic kidney disease individuals with increased levels of fibroblast growth factor-23 were independently associated with prevalent and incident AF. A higher baseline glomerular filtration rate was associated with an increased risk of AF. Elevated levels of insulin-like growth factor binding protein-7 were also observed in AF patients, while reduced circulating tissue inhibitor of metalloproteinase 2 levels were also associated with an increased risk of AF. Patients with AF had higher levels of non-esterified fatty acids and liver type fatty acid binding protein. Interleukin-18 levels in blood plasma were also found to be higher in AF patients. Furthermore, higher baseline urea/blood urea nitrogen levels were significantly associated with the incidence of AF in women and kidney disease in both men and women.
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