一例年轻男性慢性钙化性胰腺炎合并继发糖尿病和肝脾脓肿病例报告

IF 1.5 Q3 GASTROENTEROLOGY & HEPATOLOGY Gastroenterology Insights Pub Date : 2022-09-19 DOI:10.3390/gastroent13030031
C. Marginean, M. Popescu, C. Vasile, M. Stanciu, I. Popescu, V. Biciușcă, D. Ciobanu, A. Dobrescu, L. Sandulescu, S. Bondari, Marian-Sorin Popescu, P. Mitruț
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引用次数: 1

摘要

背景:慢性胰腺炎(CP)被描述为一种多因素的、持续的、强度不同的胰腺炎症状况,可产生持续的疼痛,导致外分泌和内分泌功能不全以及寿命缩短。目前,慢性胰腺炎主要有三种形式:慢性自身免疫性胰腺炎(类固醇敏感性胰腺炎)、慢性阻塞性胰腺炎和慢性钙化性胰腺炎,后者与症状出现前1年甚至20年的过量饮酒密切相关。病例报告:我们提出的情况下,一个29岁的男子谁需要医疗照顾显著无意体重减轻和上腹部疼痛的历史。血液检查显示有明显异常,病人被送进医院接受进一步检查。CT和MRI证实胰腺假性囊肿和广泛的胰腺实质钙化的存在,并显示多发性肝脾微脓肿的真菌病因。结论:慢性钙化性胰腺炎是一种复杂的临床实体,由于胰腺实质的进行性破坏,可导致继发性糖尿病。由吸收不良综合征、免疫细胞功能障碍和糖尿病引起的高糖环境引起的蛋白质营养不良可能造成免疫缺陷状态,使患者容易发生机会性感染。
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Chronic Calcifying Pancreatitis Associated with Secondary Diabetes Mellitus and Hepatosplenic Abscesses in a Young Male Patient: A Case Report
Background: Chronic pancreatitis (CP) has been described as a multifactorial, ongoing inflammatory condition of the pancreas of varying intensity that produces persistent pain, leading to exocrine and endocrine insufficiency and a decreased lifespan. Currently, there are three primary forms of chronic pancreatitis: chronic autoimmune pancreatitis (steroid-sensitive pancreatitis), chronic obstructive pancreatitis, and chronic calcific pancreatitis, the latter being closely related to excessive alcohol consumption for one or even two decades before the onset of symptoms. Case report: We present the case of a 29 year old man who required medical attention for a significant unintentional weight loss and a history of upper abdominal pain. Blood tests revealed substantial abnormalities, and the patient was admitted for further investigation. CT and MRI confirmed the presence of a pancreatic pseudocyst and extensive pancreatic parenchymal calcifications and revealed multiple hepatosplenic microabscesses of fungal etiology. Conclusions: Chronic calcifying pancreatitis is a complex clinical entity that can lead to secondary diabetes due to progressive destruction of the pancreatic parenchyma. Protein malnutrition, caused by malabsorption syndrome, immune cell dysfunction, and a high glucose environment caused by diabetes mellitus, may create a state of immunodeficiency, predisposing the patient to opportunistic infections.
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来源期刊
Gastroenterology Insights
Gastroenterology Insights GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
2.80
自引率
3.40%
发文量
35
审稿时长
10 weeks
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