先前由流感、单纯疱疹或爱泼斯坦-巴尔病毒引起的传染病作为生物威胁因子与多发性硬化症复发发作的关系

IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL Romanian Journal of Military Medicine Pub Date : 2022-11-01 DOI:10.55453/rjmm.2022.125.4.19
M. Hashemzadeh
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引用次数: 0

摘要

“尽管多发性硬化症(MS)是年轻人最常见的神经系统疾病,困扰着全世界数十万人,其发病机制至今仍不完全清楚。疾病机制似乎存在显著的异质性,但在大多数情况下,假设自身免疫起源或至少是决定性的自身免疫成分。因此,病原学研究的重点是免疫系统编程的不同参与者。本研究检测了人类粘病毒抗性蛋白A(MxA)、抗EBNA抗体和白细胞介素S10-12-17等生物标志物。假说研究表明:实验组MS患者(有复发的患者)血液中白细胞介素水平高于对照组(无复发情况的患者)。其他组(复发患者)和对照组(无复发情况的患者)的MS患者的抗EBNA抗体水平较高。实验组多发性硬化症患者(复发患者)的人类粘病毒抗性蛋白A(MxA)水平低于对照组(无复发情况的患者)。其他组(复发患者)和对照组(无复发情况的患者)的MS患者的抗EBNA抗体水平较高。“
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The relationship between a previous infectious disease caused by influenza, herpes simplex, or Epstein-Barr viruses as the biological threatening agents with recurrent episodes of multiple sclerosis
"Although multiple sclerosis (MS) is the most common neurological disease of young adults, afflicting hundreds of thousands of people worldwide, its pathogenesis is still only incompletely understood. There seems to be substantial heterogeneity in disease mechanisms, but in the majority of cases an autoimmune origin or at least a decisive autoimmune component is postulated. Therefore, pathogenic research focuses on different players programmed by the immune system. In this study, biomarkers such as Human myxovirus resistance protein A (MxA), Anti-EBNA antibody and Interleukin S10-12- 17 have been tested. Study of hypotheses show that: Interleukin levels in the blood of MS patients in the experimental group (patients with recurrence) is higher than controls (patients without recurrence condition). The level of anti-EBNA antibody in MS patients in other groups (patients with recurrent) and control group (patients without recurrence condition) is high. The level of the human myxovirus resistance protein A (MxA) in patients with multiple sclerosis in the experimental group (patients with recurrence) is less than the control group (patients without recurrence condition). The level of anti-EBNA antibody in MS patients in other groups (patients with recurrent) and control group (patients without recurrence condition) is high."
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来源期刊
Romanian Journal of Military Medicine
Romanian Journal of Military Medicine MEDICINE, GENERAL & INTERNAL-
自引率
33.30%
发文量
2
审稿时长
12 weeks
期刊最新文献
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