D. He, Xiaotong Wang, Bingrong Liu, Jiansheng Li, Dan Liu, Pu Zheng, Yanyan Zheng
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引用次数: 0
摘要
目的评价内镜下抗反流黏膜切除术治疗胃食管反流病的疗效和安全性。方法回顾性分析2015年12月至2018年7月在郑州大学第一附属医院接受内镜下抗反流粘膜切除术的18例胃食管反流病患者的资料。分析治疗效果（改善烧心和反流症状，24小时食管pH值监测）和并发症。结果所有患者均成功实施了抗反流粘膜切除术，成功率100%。ESD 8例，EMR 10例。24小时食管pH监测结果显示，治疗后Demester评分、pH<4的时间百分比、总反流事件和pH<4超过5分钟的反流次数显著低于治疗前（20.16±9.12 VS 74.16±20.03，（2.70±0.88）%VS（6.42±1.37）%，43.78±19.68 VS 156.56±41.22，2.89±1.68 VS 9.89±2.95，P均<0.05）。在3-34个月的随访期间，症状缓解率为89%（16/18）。18例患者出现心脏紧缩，16例患者出现粘膜损伤恢复。结论抗反流粘膜切除术治疗胃食管反流病安全、有效、操作简便。关键词：胃食管反流；抗反流粘膜切除术；内镜治疗
Clinical evaluation of endoscopic anti-reflux mucosectomy for gastroesophageal reflux disease
Objective
To assess the efficacy and safety of the endoscopic anti-reflux mucosectomy for gastroesophageal reflux disease.
Methods
Data of 18 patients with gastroesophageal reflux disease who underwent endoscopic anti-reflux mucosectomy at the First Affiliated Hospital of ZhengZhou University from December 2015 to July 2018 were retrospectively studied. The therapeutic effects (improvement of heartburn and reflux symptoms, 24 h esophageal pH monitoring) and complications were analyzed.
Results
Anti-reflux mucosectomy was performed successfully in all patients with successful rate of 100%. ESD was performed in 8 cases and EMR in 10 cases.24 h esophageal pH monitoring results showed that the Demeester score, the time percentage of pH < 4, total reflux events and reflux times of pH < 4 with time longer than 5 minutes after treatment were significantly lower than those before treatment (20.16±9.12 VS 74.16±20.03, (2.70±0.88)% VS (6.42±1.37)%, 43.78±19.68 VS 156.56±41.22, 2.89±1.68 VS 9.89±2.95, all P<0.05). No bleeding, perforation or infection was observed after the procedure. During a follow-up period of 3-34 months, symptom relief rate was 89% (16/18). A tightened cardiac was noted in 18 cases and recovery of mucosal damage was found in 16 patients.
Conclusion
Anti-reflux mucosectomy is safe, effective and easy to operate for gastroesophageal reflux disease.
Key words:
Gastroesophageal reflux; Anti-reflux mucosectomy; Endoscopic therapy
期刊介绍：
Chinese Journal of Digestive Endoscopy is a high-level medical academic journal specializing in digestive endoscopy, which was renamed Chinese Journal of Digestive Endoscopy in August 1996 from Endoscopy.
Chinese Journal of Digestive Endoscopy mainly reports the leading scientific research results of esophagoscopy, gastroscopy, duodenoscopy, choledochoscopy, laparoscopy, colorectoscopy, small enteroscopy, sigmoidoscopy, etc. and the progress of their equipments and technologies at home and abroad, as well as the clinical diagnosis and treatment experience.
The main columns are: treatises, abstracts of treatises, clinical reports, technical exchanges, special case reports and endoscopic complications.
The target readers are digestive system diseases and digestive endoscopy workers who are engaged in medical treatment, teaching and scientific research.
Chinese Journal of Digestive Endoscopy has been indexed by ISTIC, PKU, CSAD, WPRIM.
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