一种新型高浓度透明质酸填充物用于面部全面嫩肤——附35例描述性分析

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Cosmetics Pub Date : 2023-07-17 DOI:10.3390/cosmetics10040105
M. Issa, André Fogaça, E. Palermo, Luciana C. Maluf, Patricia Ormiga, L. Conrado, Luis Henrique Barbizan de Moura
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引用次数: 0

摘要

在过去的几十年里,使用填充物的美容手术变得越来越重要,因为它们能够快速提供恢复活力和美化,而且没有(或轻微)副作用。透明质酸凝胶是美容皮肤科使用最多的填充剂;它的物理和化学性质根据制造过程而变化。最终产品的特性对其临床适应症至关重要。透明质酸凝胶需要特定的物理化学性质来填充、填充、维持和轮廓不同的解剖区域和层。理想情况下,透明质酸凝胶应该具有与周围组织相似的稠度,以促进自然的感觉,但与此同时,它们应该能够在模拟运动中由肌肉收缩引起的持续物理压力下保持其形状。一般来说,较软的凝胶是用来填充浅层的,而不是用来做提拉或填充的,因此建议使用较硬的凝胶。因此,建议结合不同特性的凝胶进行全面面部治疗。巴西市场最近推出了一种新的韩国HA填充剂。然而,使用这些产品的全球面部治疗的临床评估在文献中是缺乏的。本研究旨在描述使用这些填充物进行面部治疗的临床结果、患者满意度和副作用。我们分析了7位皮肤科医生对35名患者进行的全面面部治疗的临床影响。包括渴望美容或返老还童的两性患者,他们都有填充手术的适应症。使用了三种韩国HA凝胶(例如:S100、S300和S500, Jetema®),它们具有高HA浓度和黏结性,仅在交联度上有所不同。皮肤科医生根据其流变学特性和临床评估为每个程序选择产品。S100凝胶用于细化,S300和S500凝胶用于结构和体积。在手术后1、3和6个月,医生使用全球美学改善量表(GAIS)评估恢复或美化的临床结果,并使用李克特量表评估患者满意度。其中男性4例,女性31例,平均年龄43.08岁。平均使用6.33支注射器。30天后,80%的患者表现出良好或强化的改善,满意度为94.2%。3个月和6个月后,80%的患者表现出良好或强化的改善,这增加了他们的幸福感(97%)。17例患者立即出现常见副作用。一名患者有血管闭塞,使用透明质酸酶后迅速恢复。大多数患者改善明显,满意度高。这种新的内聚性,高度浓缩的透明质酸凝胶促进了持续的整体改善和患者满意度,预期的短暂副作用。
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Global Facial Rejuvenation Using a New Cohesive, Highly Concentrated Hyaluronic Acid Filler: A Descriptive Analysis of 35 Cases
Cosmetic procedures using fillers have gained importance over the last decades due to their ability to offer rejuvenation and beautification quickly with no (or minor) side effects. Hyaluronic acid (HA) gel is the most used filler in cosmetic dermatology; its physical and chemical properties vary according to the manufacturing process. The characteristics of the final product are crucial for its clinical indication. Specific physicochemical properties of HA gel are required to fill, volumize, sustain, and contour different anatomical areas and layers. Ideally, HA gels should have a consistency similar to that of the surrounding tissue to promote a natural feel, but, at the same time, they should be able to sustain their shape against constant physical strain caused by muscle contraction during mimic movements. Generally, softer gels are indicated to fill superficial layers, and are not usually meant to perform lifting or volumizing, for which stiffer gels are proposed. Therefore, combining gels with different characteristics is indicated for global facial treatment. The Brazilian market recently introduced a new Korean HA filler. Still, clinical evaluation of global facial treatment using these products is lacking in the literature. This study aims to describe clinical results, patient satisfaction, and side effects of facial treatment using these fillers. We analysed the clinical impact of global facial treatment in 35 patients performed by seven dermatologists. Patients of both sexes desiring beautification or rejuvenation were included, and all of them had indications for the filling procedure. Three Korean HA gels (e.p.t.q. S100, S300, and S500, Jetema ®) with high HA concentrations and cohesiveness, varying only in their crosslinking degree, were used. The dermatologists chose the product for each procedure based on their rheological properties and clinical assessment. S100 gel was indicated for refinement, and S300 and S500 gels for structure and volume. The doctors evaluated the clinical outcomes of rejuvenation or beautification using the Global Aesthetic Improvement Scale (GAIS), and patient satisfaction using the Likert scale, 1, 3, and 6 months after the procedures. Patients treated included 4 males and 31 females with a mean age of 43.08 years. An average of 6.33 syringes was used. After 30 days, 80% of patients showed excellent or accentuated improvement, with 94.2% satisfaction. After 3 and 6 months, 80% of patients showed excellent or accentuated improvement, which increased their happiness (97%). Immediate common side effects occurred in 17 patients. One patient had a vascular occlusion, which was quickly reverted using hyaluronidase. Most patients had accentuated improvement and great satisfaction. This new cohesive, highly concentrated HA gel promoted a sustained global improvement and patient satisfaction with expected transitory side effects.
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来源期刊
Cosmetics
Cosmetics Medicine-Surgery
CiteScore
5.20
自引率
12.10%
发文量
108
审稿时长
8 weeks
期刊最新文献
Microtopography and Barrier Function in Healthy Skin: Differences between Forearm, Cheek and Palm An Assessment of the Effectiveness and Safety of ULTRACOL100 as a Device for Restoring Skin in the Nasolabial Fold Region Simultaneous Skin Rejuvenation in Patients Undergoing Medical Treatment for Actinic Keratosis and Non-Melanoma Skin Cancer: A Case Series Analysis The Potential of Grapevine Leaf Extract in Treating Hyperpigmentation Meta-Analysis and Analytical Methods in Cosmetics Formulation: A Review
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