{"title":"圆底烧瓶法制备双氯芬酸钠乳质体及评价","authors":"Sankha Bhattacharya","doi":"10.22377/ajp.v14i2.3613","DOIUrl":null,"url":null,"abstract":"Aim: The main objective of this study is to prepare and evaluate niosomes as a carrier for diclofenac sodium. Niosomes are bilayer microparticles formed by self-association of non-ionic surfactant and cholesterol after hydration in the aqueous phase. Materials and Methods: Niosomes of SPAN-60 and cholesterol were prepared in three batches (A, B, and C) with different ratio (5:5, 6:4, and 7:3) using a round bottom flask method. Prepared niosomes were evaluated for entrapment efficiency, particle size analysis, and morphology and in vitro drug release study. Results and Discussion: The entrapment efficiency of all three formulations was found to be 91.43%, 92.53%, and 92.33%, respectively. All formulations were observed under motic microscope and particles were assumed to be spherical in shape. The average particle size of all the three batches was analyzed by Zetasizer (Delsa C Particle Analyzer), and it was found that the batch C produced the best nano-sized formulation with an average particle diameter of 311.6 nm. In vitro release study was done using a dialysis bag and after 300 min of studies, batch C (7:3), which was found to have 68.6 ± 1.4% cumulative drug release, which indicates controlled and steady drug release profiling of the formulation. Conclusion: After comparing all three batches of evaluation results on the basis of drug entrapment, particle size analysis, morphology, and in vitro drug release study, Batch C (7:3) formulation was considered as the best formulation.","PeriodicalId":8489,"journal":{"name":"Asian Journal of Pharmaceutics","volume":" ","pages":""},"PeriodicalIF":0.4000,"publicationDate":"2020-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"Preparation and Evaluation of Diclofenac Sodium Niosomes Using Round Bottom Flask Method\",\"authors\":\"Sankha Bhattacharya\",\"doi\":\"10.22377/ajp.v14i2.3613\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aim: The main objective of this study is to prepare and evaluate niosomes as a carrier for diclofenac sodium. Niosomes are bilayer microparticles formed by self-association of non-ionic surfactant and cholesterol after hydration in the aqueous phase. Materials and Methods: Niosomes of SPAN-60 and cholesterol were prepared in three batches (A, B, and C) with different ratio (5:5, 6:4, and 7:3) using a round bottom flask method. Prepared niosomes were evaluated for entrapment efficiency, particle size analysis, and morphology and in vitro drug release study. Results and Discussion: The entrapment efficiency of all three formulations was found to be 91.43%, 92.53%, and 92.33%, respectively. All formulations were observed under motic microscope and particles were assumed to be spherical in shape. The average particle size of all the three batches was analyzed by Zetasizer (Delsa C Particle Analyzer), and it was found that the batch C produced the best nano-sized formulation with an average particle diameter of 311.6 nm. In vitro release study was done using a dialysis bag and after 300 min of studies, batch C (7:3), which was found to have 68.6 ± 1.4% cumulative drug release, which indicates controlled and steady drug release profiling of the formulation. Conclusion: After comparing all three batches of evaluation results on the basis of drug entrapment, particle size analysis, morphology, and in vitro drug release study, Batch C (7:3) formulation was considered as the best formulation.\",\"PeriodicalId\":8489,\"journal\":{\"name\":\"Asian Journal of Pharmaceutics\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2020-06-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Journal of Pharmaceutics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22377/ajp.v14i2.3613\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Pharmaceutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22377/ajp.v14i2.3613","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Preparation and Evaluation of Diclofenac Sodium Niosomes Using Round Bottom Flask Method
Aim: The main objective of this study is to prepare and evaluate niosomes as a carrier for diclofenac sodium. Niosomes are bilayer microparticles formed by self-association of non-ionic surfactant and cholesterol after hydration in the aqueous phase. Materials and Methods: Niosomes of SPAN-60 and cholesterol were prepared in three batches (A, B, and C) with different ratio (5:5, 6:4, and 7:3) using a round bottom flask method. Prepared niosomes were evaluated for entrapment efficiency, particle size analysis, and morphology and in vitro drug release study. Results and Discussion: The entrapment efficiency of all three formulations was found to be 91.43%, 92.53%, and 92.33%, respectively. All formulations were observed under motic microscope and particles were assumed to be spherical in shape. The average particle size of all the three batches was analyzed by Zetasizer (Delsa C Particle Analyzer), and it was found that the batch C produced the best nano-sized formulation with an average particle diameter of 311.6 nm. In vitro release study was done using a dialysis bag and after 300 min of studies, batch C (7:3), which was found to have 68.6 ± 1.4% cumulative drug release, which indicates controlled and steady drug release profiling of the formulation. Conclusion: After comparing all three batches of evaluation results on the basis of drug entrapment, particle size analysis, morphology, and in vitro drug release study, Batch C (7:3) formulation was considered as the best formulation.
期刊介绍:
Character of the publications: -Pharmaceutics and Pharmaceutical Technology -Formulation Design and Development -Drug Discovery and Development Interface -Manufacturing Science and Engineering -Pharmacokinetics, Pharmacodynamics, and Drug Metabolism -Clinical Pharmacology, General Medicine and Translational Research -Physical Pharmacy and Biopharmaceutics -Novel Drug delivery system -Biotechnology & Microbiological evaluations -Regulatory Sciences