圆底烧瓶法制备双氯芬酸钠乳质体及评价

IF 0.4 Q4 PHARMACOLOGY & PHARMACY Asian Journal of Pharmaceutics Pub Date : 2020-06-09 DOI:10.22377/ajp.v14i2.3613
Sankha Bhattacharya
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引用次数: 6

摘要

目的:制备双氯芬酸钠载体并对其进行评价。乳小体是由非离子表面活性剂与胆固醇在水相中水化后自结合形成的双层微粒。材料与方法:采用圆底烧瓶法,按不同比例(5:5、6:4、7:3),分A、B、C三批制备pan -60和胆固醇脂质体。对制备的纳米体进行包封效率、粒径分析、形态和体外药物释放研究。结果与讨论:3种制剂的捕集率分别为91.43%、92.53%、92.33%。在运动显微镜下观察所有配方,并假设颗粒为球形。采用Zetasizer (Delsa C颗粒分析仪)对三批产品的平均粒径进行分析,发现C批产品的平均粒径为311.6 nm,为最佳纳米配方。体外释药研究采用透析袋进行,研究300 min后,C批(7:3)的累积释药量为68.6±1.4%,表明该制剂具有可控、稳定的释药特性。结论:通过药物包封、粒度分析、形貌及体外释药研究对三批评价结果进行比较,认为C批(7:3)处方为最佳处方。
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Preparation and Evaluation of Diclofenac Sodium Niosomes Using Round Bottom Flask Method
Aim: The main objective of this study is to prepare and evaluate niosomes as a carrier for diclofenac sodium. Niosomes are bilayer microparticles formed by self-association of non-ionic surfactant and cholesterol after hydration in the aqueous phase. Materials and Methods: Niosomes of SPAN-60 and cholesterol were prepared in three batches (A, B, and C) with different ratio (5:5, 6:4, and 7:3) using a round bottom flask method. Prepared niosomes were evaluated for entrapment efficiency, particle size analysis, and morphology and in vitro drug release study. Results and Discussion: The entrapment efficiency of all three formulations was found to be 91.43%, 92.53%, and 92.33%, respectively. All formulations were observed under motic microscope and particles were assumed to be spherical in shape. The average particle size of all the three batches was analyzed by Zetasizer (Delsa C Particle Analyzer), and it was found that the batch C produced the best nano-sized formulation with an average particle diameter of 311.6 nm. In vitro release study was done using a dialysis bag and after 300 min of studies, batch C (7:3), which was found to have 68.6 ± 1.4% cumulative drug release, which indicates controlled and steady drug release profiling of the formulation. Conclusion: After comparing all three batches of evaluation results on the basis of drug entrapment, particle size analysis, morphology, and in vitro drug release study, Batch C (7:3) formulation was considered as the best formulation.
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来源期刊
Asian Journal of  Pharmaceutics
Asian Journal of Pharmaceutics PHARMACOLOGY & PHARMACY-
自引率
0.00%
发文量
47
期刊介绍: Character of the publications: -Pharmaceutics and Pharmaceutical Technology -Formulation Design and Development -Drug Discovery and Development Interface -Manufacturing Science and Engineering -Pharmacokinetics, Pharmacodynamics, and Drug Metabolism -Clinical Pharmacology, General Medicine and Translational Research -Physical Pharmacy and Biopharmaceutics -Novel Drug delivery system -Biotechnology & Microbiological evaluations -Regulatory Sciences
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