Coronary arterial disease correlates with constitutions of Traditional Chinese Medicine: A cross-sectional study in a Chinese cohort

Introduction: This study aimed to explore the associations between constitutions of traditional Chinese medicine (TCM) and coronary artery disease (CAD).Methods: A large-scale, community-based, cross-sectional study was performed to investigate the associations. A total of 3,748 participants were available for analysis in this study. The assessment of the constitution of TCM was based on recommendations by the Association for Chinese Medicine in China. In this study, a diagnosis of CAD was based on self-reported medical history. The associations were analyzed using univariate and multivariable logistic regression (MLR).Results: Univariate analysis showed Phlegm–dampness, Qi-deficiency, Yang-deficiency and Yin-deficiency constitutions were significantly associated with CAD, respectively ([Formula: see text] for Phlegm–dampness, [Formula: see text] for Qi-deficiency, [Formula: see text] for Yang-deficiency and [Formula: see text] for Yin-deficiency). Furthermore, MLR demonstrated significant associations among the four constitutions and CAD, after controlling for potential confounding factors (Phlegm–dampness: [Formula: see text], [Formula: see text]; Qi-deficient: [Formula: see text], [Formula: see text], Yang-Deficient: [Formula: see text], [Formula: see text]; Yin-deficient: [Formula: see text], [Formula: see text]). As compared with Neutral participants, participants with the four constitutions of TCM had higher prevalence of CAD.Conclusion: Our findings provided evidence that the four constitutions of TCM including Phlegm-dampness, Qi-deficiency, Yan-deficiency and Yin-deficiency were significantly associated with CAD, respectively. (This study was registered in clinicaltrials.gov with the ID: NCT02998944.)