我们能提高无症状金属对金属全髋关节炎的筛查成本吗?

J. R. Martin, Jesse E. Otero, B. Springer, W. Griffin
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引用次数: 0

摘要

引言:由于失败率高,金属对金属(MoM)全髋关节置换术(THA)在美国已被大量放弃。许多失败归因于局部组织不良反应(ALTR)。因此,按照美国食品药品监督管理局的建议,患有MoM THA的患者每两年通过检查血清金属离子水平进行常规筛查。然而,关于目前筛查方案的成本数据有限。材料和方法:回顾性纳入318例在单一机构接受MoM THA的连续患者。平均随访8.2年。前瞻性收集临床数据、金属离子水平、翻修和再手术率。计算了该患者群体的临床筛查成本,并将其与年度筛查方案的成本进行了比较。结果:12例患者的Co或Cr水平升高(>4.5ppb)。对8例患者进行ALTR二次修正。研究期间筛查的总费用为612250美元。此外,如果每年进行一次筛查,筛查费用总额约为1719200美元。讨论:以下研究中的8名患者被修正为ALTR二级患者,筛查总成本为612500美元。这些费用大大低于每年筛查的费用(1719200美元)。由于筛查无症状MoM-THA患者的成本相当高,我们建议优化筛查频率并评估植入物筛查的具体风险。
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Can We Improve Screening Costs in Asymptomatic Metal on Metal Total Hip Arthroplasties?
Introduction: Metal on Metal (MoM) total hip arthroplasty (THA) has been largely abandoned in the United States secondary to high failure rates. Many of the failures are attributed to adverse local tissue reactions (ALTR). Therefore, patients that have a MoM THA are routinely screened by checking serum metal ion levels every two years, as was recommended by the FDA. However, there is limited data on the costs of current screening protocols. Materials and Methods: 318 consecutive patients who underwent a MoM THA at a single institution were retrospectively enrolled. The average follow-up was 8.2 years. Clinical data, metal ion levels, revision and reoperation rates were prospectively collected. The costs of clinical screening for this patient population was calculated and compared to the cost of an annual screening protocol. Results: 12 patients had either an elevated Co or Cr level (>4.5 ppb). Eight patients were revised secondary to ALTR. The total cost of screening during the study was $612,250. Additionally, if annual screening had been performed, total screening costs would be approximately $1,719,200. Discussion: Eight patients in the following study were revised secondary to ALTR with a total cost of screening of $612,500. These costs are substantially less than the cost of annual screening ($1,719,200). Due to the considerable costs of screening asymptomatic MoM THA patients, we recommend both optimizing the frequency of screening and evaluating the specific risk of the implant being screened. 
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