宁米台胶囊联合舍曲林治疗早泄、精囊肿大的随机临床试验

IF 2 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Journal of Traditional Chinese Medicine Pub Date : 2018-04-01 DOI:10.1016/j.jtcm.2018.04.001
Peng Longping , Hong Zhiwei , Shen Jiaming , Hu Xuechun , Shao Yong , Jing Jun , Lu Jinchun , Yao Bing
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引用次数: 2

摘要

目的探讨宁米泰胶囊联合舍曲林治疗早泄(PE)及精囊前后直径(APD)增大的疗效。方法60例获得性PE患者随机分为两组。联合组采用宁米台胶囊联合舍曲林治疗,对照组单用舍曲林治疗。主要结果采用早泄诊断工具(PEDT)、sv的APD和临床总体印象变化问卷进行测量,并比较治疗前后3个月的差异。结果两组治疗后与治疗前比较,联合治疗组PEDT评分显著降低(12.1±2.5 vs 8.6±3.2,P <0.001)和对照组(12.9±2.6 vs 10.3±1.6,P <分别为0.001)。联合治疗组治疗后PEDT评分明显低于对照组(8.6±3.2 vs 10.3±1.6,P = 0.011)。联合组svd治疗后明显降低[(10.8±2.4)vs(12.9±2.2)mm, P = 0.001],而对照组svd治疗前后相当。联合治疗组治疗有效率与对照组比较无明显差异。结论宁米台胶囊联合舍曲林治疗SVs APD增高的PE患者效果优于单用舍曲林。联合治疗的治疗效果可能是由于宁米泰胶囊的抗菌和抗炎活性,并可能提示精囊炎是获得性PE的潜在病理生理因素。
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Effect of Ningmitai capsule plus sertraline on patients with premature ejaculation and enlarged seminal vesicles: A randomized clinical trial

OBJECTIVE

To investigate the effects of Ningmitai capsule combined with sertraline on patients with premature ejaculation (PE) and an increased anterior-posterior diameter (APD) of the seminal vesicles (SVs).

METHODS

Sixty men with acquired PE were enrolled and randomly divided into two groups. The combined group was treated with Ningmitai capsule and sertraline, while the control group was treated with sertraline alone. Main outcomes were measured using the premature ejaculation diagnostic tool (PEDT), APD of SVs, and Clinical Global Impression of Change questionnaire and compared before and after 3 months of treatment.

RESULTS

Comparing after treatment with before treatment outcomes within each group, the PEDT score was significantly reduced in the combined group (12.1 ± 2.5 vs 8.6 ± 3.2, P < 0.001, respectively) and control group (12.9 ± 2.6 vs 10.3 ±1.6, P < 0.001, respectively). Furthermore, the PEDT score after treatment was significantly lower in the combined compared with control group (8.6 ± 3.2 vs 10.3 ± 1.6, P = 0.011, respectively). The APD of SVs in the combined group was significantly decreased after treatment [(10.8 ± 2.4) vs (12.9 ± 2.2) mm, P = 0.001], while the APD of SVs in the control group was equivalent before and after treatment. The treatment response rate was not significantly higher in the combined compared with control group.

CONCLUSION

These results indicated that the effect of Ningmitai capsule combined with sertraline was better than that of sertraline alone for the treatment of PE patients exhibiting an increased APD of SVs. The therapeutic effect found for the combined treatment may be due to antibacterial and anti-inflammatory activity reported for Ningmitai capsule, and may suggest that seminal vesiculitis is a potential pathophysiological factor in acquired PE.

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来源期刊
Journal of Traditional Chinese Medicine
Journal of Traditional Chinese Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
2.40
自引率
3.80%
发文量
32269
审稿时长
2 months
期刊介绍: Journal of Traditional Chinese Medicine(JTCM) is devoted to clinical and theortical research on the use of acupuncture and Oriental medicine. The main columns include Clinical Observations, Basic Investigations, Reviews, Questions and Answers, an Expert''s Forum, and Discussions of Clinical Cases. Its key topics include acupuncture and electro-acupuncture, herbal medicine, homeopathy, masseotherapy, mind-body therapies, palliative care, and other CAM therapies.
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