儿童抗N-甲基-D-天冬氨酸受体脑炎的临床表现、治疗和预后综述

Sawsan El Hussein, B. Ibrahim, W. Abdullah
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引用次数: 0

摘要

抗N-甲基-D-天冬氨酸受体脑炎是一种严重的自身免疫性疾病,由脑脊液中针对NMDAR的GluN1亚基产生的免疫球蛋白G抗体引起。它具有广泛的临床特征,包括心理表现、运动障碍和癫痫发作。静脉注射甲基强的松龙、静脉注射免疫球蛋白和血浆置换是一线治疗方法。该疾病的早期诊断、治疗、监测和随访至关重要,因为它能带来良好的预后。在儿科年龄组,复发是可能的。
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Anti-N-Methyl-D-Aspartate receptor encephalitis in pediatrics: A review of clinical manifestations, treatment, and prognosis
Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDAR) is a severe autoimmune disease caused by the development of immunoglobulin G antibodies against the NMDAR's GluN1 subunit in the cerebrospinal fluid. It is characterized by a wide range of clinical features including psychological manifestations, dyskinesia, and epileptic seizures. Intravenous methylprednisolone, intravenous immunoglobulin, and plasma exchange are the first-line treatments. Early diagnosis, treatment, monitoring, and follow-up of the disease are crucial as it results in favorable prognosis. In the pediatric age group, relapse is possible.
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