纳米异丙酚联合神经阻滞的麻醉效果

Jie Luo, Deming Wang, Wenqiang Guo, Hong Cao
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引用次数: 1

摘要

上肢手术麻醉是临床上常用的麻醉方法。目前,传统的神经阻滞方法采用解剖定位,可能导致局部阻滞不完全,降低麻醉效果。相反,超声引导的神经阻滞可以帮助临床医生直观地掌握患者组织的结构,并提供针穿入的实时显示。异丙酚是世界上最常用的静脉麻醉剂,但它的使用仍然有限。为了改善该药物的局限性,我们开发了一种异丙酚纳米乳,并将其与下臂丛阻滞联合使用。本研究将100例患者随机分为两组,每组50例。实验组采用神经阻滞用纳米异丙酚注射液,对照组采用氯胺酮。比较两组手术质量、呼吸抑制/窒息、恢复时间、OPS评分、躁动评分及并发症。两组患者失血量差异无统计学意义(P < 0.05)。实验结果表明,下臂丛阻滞和异丙酚纳米乳在手术中的镇痛效果优于氯胺酮和异丙酚纳米乳。
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Anesthesia Effect of Propofol Nanoinjection Combined with Nerve Block
Anesthesia for upper limb surgery is commonly used in clinical practice. At present, the traditional method uses anatomical localization for nerve block, which can result incomplete local block and reduced anesthetic effect. Instead, ultrasound-guided nerve block can help clinicians intuitively grasp structure of patient tissues and provide a real-time display of needle penetration. Propofol is the most commonly used intravenous anesthetic in the world, but its use is still limited. In order to improve the limitations of this drug, a propofol nanoemulsion was developed and used in combination with a lower brachial plexus block. In this study, 100 patients were randomly divided into two groups, 50 in each group. The propofol nanoinjection for nerve block was used in the experimental group and ketamine was used in the control group. The quality of the operation, respiratory inhibition/asphyxia, recovery time, OPS score, agitation score, and complications were compared between the two groups. There was no significant difference in blood loss between the two groups (P > 0 05). The experimental results showed that the lower brachial plexus block and propofol nanoemulsion provided a better analgesic effect than ketamine and propofol nanoemulsion in the operation.
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来源期刊
Nanoscience and Nanotechnology Letters
Nanoscience and Nanotechnology Letters Physical, Chemical & Earth Sciences-MATERIALS SCIENCE, MULTIDISCIPLINARY
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审稿时长
2.6 months
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