Fang Liu, Yuanyuan Zhou, Wencheng Song, Hongzhi Wang
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Cold Atmospheric Plasma Inhibits the Proliferation of CAL-62 Cells through the ROS-Mediated PI3K/Akt/mTOR Signaling Pathway
This study aimed to investigate the inhibitory effects of cold atmospheric plasma (CAP) on anaplastic thyroid cancer cells (CAL-62 cells) and to reveal the molecular mechanism. The effects of CAP on CAL-62 cells were evaluated by cell viability, superoxide dismutase activity, apoptosis, cell cycle, and protein expression level, and the role of reactive oxygen species (ROS) produced by plasma was also investigated. The results showed that CAP dose-dependently inhibited cell viability and promotes cell apoptosis and G2/M arrest by increasing cell ROS levels. The activity of superoxide dismutase (SOD) was enhanced by CAP which indicated that the antioxidant system of the cell was activated. Additionally, the ROS produced by CAP can inhibit CAL-62 cell proliferation by inhibiting the PI3K/Akt/mTOR signaling pathway. Therefore, these findings will provide useful support for the application of CAP for treating anaplastic thyroid cancer.
期刊介绍：
Science and Technology of Nuclear Installations is an international scientific journal that aims to make available knowledge on issues related to the nuclear industry and to promote development in the area of nuclear sciences and technologies. The endeavor associated with the establishment and the growth of the journal is expected to lend support to the renaissance of nuclear technology in the world and especially in those countries where nuclear programs have not yet been developed.
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