{"title":"癌症与肺炎和肺炎衣原体感染的关系","authors":"J. Zakhour, D. Muller, Alex Glynn, J. Bordón","doi":"10.55504/2473-2869.1227","DOIUrl":null,"url":null,"abstract":"Introduction: The degree of association and type of causal versus non-causal relationship between pneumonia and lung cancer (LC) are evolving discussions. We reviewed English- language publications on the degree of association between pneumonia and subsequent LC. Methods: We searched the PubMed database using key- words for pneumonia, LC, and Chlamydia infection. We selected peer-reviewed studies of patients with pneumonia and LC. Case reports and other literature reviews were excluded from this review. Results: Five studies examined the incidence and/or risk of LC for a total of 415,750 patients, and four studies examined cases with Chlamydia pneumoniae chronic infection at the time of diagnosis of LC for a total of 1,467 patients. The overall risk and/or incidence of LC after pneumonia was from 2.3% to 10% for a median follow-up ranging from 109 days to 4.2 years. Three studies reported current tobacco smok- ing status, which ranged from 27.7% to 45% among those with LC. A history of prior malignancy was reported in 22.5% of patients with LC. Chlamydia immunoglobulin (Ig) A and LC were statistically non-significantly associated regardless of the age of the patients. In one study, Chlamydia heat shock protein (HSP)-60 IgG ≥ 1:50 was associated with significantly increased odds of LC in two respective models (odds ratios of [95% confidence interval (CI) 1.06–1.69] and 1.30 [95% CI 1.02–1.67]). A fourth study reported C. pneumoniae IgA ≥ 64 titers to be 58%, 29%, and 5.5% among patients with LC, those without LC, and healthy blood donors, respectively. Conclusions: The incidence of LC was reported to range from 2.3% to 10.3% following an episode of pneumonia. There is limited evidence of the association of chronic Chlamydia infection with LC, and Chlamydia could be a causal cofactor of LC. causal cofactor of lung cancer. Metagenomic studies are needed to examine the changes in the lung microbiome triggering upregulation of the P13K signaling pathway.","PeriodicalId":91979,"journal":{"name":"The University of Louisville journal of respiratory infections","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Association of Lung cancer with Pneumonia and Chlamydia pneumoniae infection\",\"authors\":\"J. Zakhour, D. Muller, Alex Glynn, J. Bordón\",\"doi\":\"10.55504/2473-2869.1227\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: The degree of association and type of causal versus non-causal relationship between pneumonia and lung cancer (LC) are evolving discussions. We reviewed English- language publications on the degree of association between pneumonia and subsequent LC. Methods: We searched the PubMed database using key- words for pneumonia, LC, and Chlamydia infection. We selected peer-reviewed studies of patients with pneumonia and LC. Case reports and other literature reviews were excluded from this review. Results: Five studies examined the incidence and/or risk of LC for a total of 415,750 patients, and four studies examined cases with Chlamydia pneumoniae chronic infection at the time of diagnosis of LC for a total of 1,467 patients. The overall risk and/or incidence of LC after pneumonia was from 2.3% to 10% for a median follow-up ranging from 109 days to 4.2 years. Three studies reported current tobacco smok- ing status, which ranged from 27.7% to 45% among those with LC. A history of prior malignancy was reported in 22.5% of patients with LC. Chlamydia immunoglobulin (Ig) A and LC were statistically non-significantly associated regardless of the age of the patients. In one study, Chlamydia heat shock protein (HSP)-60 IgG ≥ 1:50 was associated with significantly increased odds of LC in two respective models (odds ratios of [95% confidence interval (CI) 1.06–1.69] and 1.30 [95% CI 1.02–1.67]). A fourth study reported C. pneumoniae IgA ≥ 64 titers to be 58%, 29%, and 5.5% among patients with LC, those without LC, and healthy blood donors, respectively. Conclusions: The incidence of LC was reported to range from 2.3% to 10.3% following an episode of pneumonia. There is limited evidence of the association of chronic Chlamydia infection with LC, and Chlamydia could be a causal cofactor of LC. causal cofactor of lung cancer. Metagenomic studies are needed to examine the changes in the lung microbiome triggering upregulation of the P13K signaling pathway.\",\"PeriodicalId\":91979,\"journal\":{\"name\":\"The University of Louisville journal of respiratory infections\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-10-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The University of Louisville journal of respiratory infections\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.55504/2473-2869.1227\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The University of Louisville journal of respiratory infections","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.55504/2473-2869.1227","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
导论:肺炎与肺癌(LC)之间的关联程度和因果关系与非因果关系的类型正在不断发展。我们回顾了关于肺炎与随后的LC之间关联程度的英文出版物。方法:以肺炎、LC、衣原体感染为关键词检索PubMed数据库。我们选择了肺炎和LC患者的同行评议研究。病例报告和其他文献综述被排除在本综述之外。结果:5项研究调查了LC的发病率和/或风险,共415,750例患者,4项研究调查了LC诊断时肺炎衣原体慢性感染的病例,共1,467例患者。在109天至4.2年的中位随访期间,肺炎后LC的总体风险和/或发生率为2.3%至10%。三项研究报告了目前的吸烟状况,在LC患者中吸烟的比例从27.7%到45%不等。22.5%的LC患者有既往恶性肿瘤病史。衣原体免疫球蛋白(Ig) A和LC与患者年龄无关,无统计学意义。在一项研究中,衣原体热休克蛋白(HSP)-60 IgG≥1:50与两个模型中LC的几率显著增加相关(比值比为[95%置信区间(CI) 1.06-1.69]和1.30 [95% CI 1.02-1.67])。第四项研究报道,在LC患者、无LC患者和健康献血者中,肺炎原体IgA≥64滴度分别为58%、29%和5.5%。结论:据报道,肺炎发作后LC的发生率为2.3%至10.3%。慢性衣原体感染与LC相关的证据有限,衣原体可能是LC的一个因果辅助因素。肺癌的辅助因素。需要宏基因组研究来检查肺微生物组的变化触发P13K信号通路的上调。
Association of Lung cancer with Pneumonia and Chlamydia pneumoniae infection
Introduction: The degree of association and type of causal versus non-causal relationship between pneumonia and lung cancer (LC) are evolving discussions. We reviewed English- language publications on the degree of association between pneumonia and subsequent LC. Methods: We searched the PubMed database using key- words for pneumonia, LC, and Chlamydia infection. We selected peer-reviewed studies of patients with pneumonia and LC. Case reports and other literature reviews were excluded from this review. Results: Five studies examined the incidence and/or risk of LC for a total of 415,750 patients, and four studies examined cases with Chlamydia pneumoniae chronic infection at the time of diagnosis of LC for a total of 1,467 patients. The overall risk and/or incidence of LC after pneumonia was from 2.3% to 10% for a median follow-up ranging from 109 days to 4.2 years. Three studies reported current tobacco smok- ing status, which ranged from 27.7% to 45% among those with LC. A history of prior malignancy was reported in 22.5% of patients with LC. Chlamydia immunoglobulin (Ig) A and LC were statistically non-significantly associated regardless of the age of the patients. In one study, Chlamydia heat shock protein (HSP)-60 IgG ≥ 1:50 was associated with significantly increased odds of LC in two respective models (odds ratios of [95% confidence interval (CI) 1.06–1.69] and 1.30 [95% CI 1.02–1.67]). A fourth study reported C. pneumoniae IgA ≥ 64 titers to be 58%, 29%, and 5.5% among patients with LC, those without LC, and healthy blood donors, respectively. Conclusions: The incidence of LC was reported to range from 2.3% to 10.3% following an episode of pneumonia. There is limited evidence of the association of chronic Chlamydia infection with LC, and Chlamydia could be a causal cofactor of LC. causal cofactor of lung cancer. Metagenomic studies are needed to examine the changes in the lung microbiome triggering upregulation of the P13K signaling pathway.