E-modules多组分治疗对3-8岁肥胖儿童BMI的影响

E. van Hoek, E. Feskens, L. Bouwman, W. Verburgt, W. de Jager, H. Schipper, T. Vrijkotte, A. Janse
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摘要

摘要简介:儿童肥胖具有严重的健康风险,包括代谢综合征、心血管疾病和日后死亡。3至7年的关键增长期为干预措施提供了机会之窗。本研究的目标是评估一项针对年轻肥胖儿童的为期一年的多学科低强度治疗计划,该计划辅以名为“AanTafel!”的网络模块,内容涉及身体成分、心脏代谢风险状况、生活质量(HRQoL)、饮食行为和体育活动。方法:在试验前后设计中,在基线、4个月、治疗结束和基线后3年采取所有措施。结果:13名男孩和27名女孩的中位BMI z评分分别为4.2和3.3,年龄在3至8岁之间,他们开始了“AanTafel!”。80%(n=32)的患者完成了治疗。BMI z评分下降0.45(治疗结束),并在3年后持续。一开始,16.7%的儿童患有代谢综合征的所有四种成分,这一比例降至0%。HDL胆固醇显著升高。标志物IL18、e-选择素和sICAM的浓度显著降低,表明炎症减轻。结论:“安达菲”能有效改善肥胖幼儿的健康状况。超重的减少与临床相关,并在3年后持续。
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Effect on BMI of a multi-component treatment with E-modules for 3–8-year-old obese children
ABSTRACT Introduction: Childhood obesity has serious health risks including the development of metabolic syndrome, cardiovascular disease and mortality later in life. The critical growth period from 3 to 7 years provides a window of opportunity for interventions. The goal of this study is to evaluate a one year, multidisciplinary, low-intensity treatment program for young obese children, complemented with web-based modules, called “AanTafel!”, on body composition, cardiometabolic risk profile, quality of life (HRQoL), eating behavior and physical activity. Methods: In the pre-post-test design all measures were taken at baseline, 4 months, at the end of treatment and 3 years after baseline. Results: Thirteen boys and 27 girls with median BMI z-score of, respectively, 4.2 and 3.3 aged 3 to 8 started “AanTafel!”. Eighty percent (n = 32) completed treatment. BMI z-score decreased with 0.45 (end of treatment) and sustained after 3 years. At the start, 16.7% of the children had all four components of metabolic syndrome which decreased to 0%. HDL cholesterol significantly increased. Concentrations of the markers IL18, e-selectin, and sICAM significantly decreased indicating a reduction of inflammation. Conclusion: “AanTafel!” is effective in improving health of obese young children. The reduction of overweight is clinically relevant and sustained after 3 years.
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