自闭症谱系障碍中的尿生物蝶呤

IF 0.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pteridines Pub Date : 2021-01-01 DOI:10.1515/pteridines-2020-0023
A. Waligóra, A. Damasiewicz-Bodzek, P. Gorczyca, Sławomir Waligóra, K. Tyrpień-Golder
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引用次数: 0

摘要

【摘要】目的研究自闭症谱系障碍(ASD)患者尿液样本中生物蝶呤的含量是否明显低于健康人群。方法采用市售试剂盒,采用酶联免疫吸附法测定尿标本中生物蝶呤的浓度。这项研究涉及53名年龄在3-16岁的自闭症儿童和60名年龄在2-14岁的健康儿童。结果自闭症患者的生物蝶呤浓度明显低于对照组。然而,在轻度、中度和重度ASD之间没有观察到显著差异。结论四氢生物蝶呤(BH4)缺乏可能是尿中生物蝶呤水平下降的潜在原因之一,它对神经系统具有广泛而严重的健康后果。测量生物蝶呤作为BH4的完全氧化形式的结果可能表明,ASD儿童BH4的生物合成或再生可能减少。另一方面,ASD患儿尿中生物蝶呤水平下降可能与BH4过度使用、再生过程良好、尿排泄减少有关;BH4代谢异常似乎与ASD的病因有关或可能由ASD引起。
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The urinary biopterin in autism spectrum disorder
Abstract Objective The aim of the study was to determine whether biopterin is present in significantly lower quantities in urine samples of patients with autism spectrum disorder (ASD) compared to healthy individuals. Methods The concentration of biopterin in urine samples was measured by ELISA using commercially available kit. The study involved 53 children aged 3–16 years with ASD and 60 healthy children aged 2–14 years. Results Significantly lower biopterin concentration was observed in autistic patients compared to the control group. However, no significant difference was observed between mild, moderate, and severe ASD. Conclusion One of the potential causes of decrease in urinary biopterin levels may be tetrahydrobiopterin (BH4) deficiency, which has extensive and serious health consequences for the nervous system. The results of measuring biopterin as a fully oxidized form of BH4 may suggest that biosynthesis or regeneration of BH4 may be decreased in children with ASD. On the other hand, decreased urinary biopterin levels in children with ASD may be due to BH4 overuse, a good regeneration process, and decreased urinary excretion; and abnormalities in BH4 metabolism appear to be related to the aetiology of ASD or may be due to ASD.
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来源期刊
Pteridines
Pteridines 生物-生化与分子生物学
CiteScore
1.20
自引率
25.00%
发文量
6
审稿时长
>12 weeks
期刊介绍: Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.
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