老年慢性阻塞性肺疾病患者血清脂联素水平与虚弱的关系

Erika Marfiani, Jusri Ichwani, Novira Widajanti, Daniel Maranatha, M. Amin
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引用次数: 1

摘要

老年人尤其容易受到慢性阻塞性肺病(COPD)对健康的不利影响。COPD是一种典型的衰老疾病,在64岁以上的年龄组中约占12%。虚弱是一种重要的老年综合征,而脂联素是一种调节能量稳态的重要脂肪因子。脂联素受年龄影响,尤其是男性。随着老年男性皮下脂肪细胞的减少,脂联素水平增加。脂联素增加会导致肌肉萎缩,从而进一步降低体重和体重指数(BMI),从而间接增加虚弱程度。到目前为止,脂联素与晚期COPD虚弱程度之间的关系尚不清楚。本研究旨在探讨COPD老年人血浆脂联素水平与虚弱的关系。这是一项观察分析横断面研究。测量了所有人体测量参数,包括体重、身高和体重指数(BMI)。通过从静脉血样本中获得的ELISA方法测定脂联素。年龄大于或等于60岁的患者接受肺活量测定,以确定Fried标准定义的气流限制程度和虚弱程度。统计分析采用秩斯皮尔曼。38名男性COPD患者成为研究对象。平均年龄为70-74岁,共有13名健壮、12名预备役和13名虚弱患者。健壮组、运动前组和虚弱组的脂联素水平(平均值和标准差)分别为6.84+2.66、6.58+4.27和11.62+4.90,p=0.015。进一步的分析表明,脂联素水平随着虚弱成分数量的增加而逐渐升高。梗阻程度多为轻度(42.1%),无极重度。所有受试者血清脂联素水平均升高。总之,血清脂联素水平与虚弱程度呈正相关。
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RELATIONSHIP BETWEEN LEVEL OF SERUM ADIPONECTIN AND FRAILTY IN ELDERLY PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Elderly are especially prone to the adverse health effects of chronic obstructive pulmonary disease (COPD). COPD is a typical aging disease which is found to be about 12% in the age group more than 64 years old. Frailty is an important geriatics syndrome, while adiponectin is an important adipokine that regulate homeostasis of energy. Adiponectin is affected by age, especially in males. Adiponectin levels increases as subcutaneous fat cells in older men decreases. Increased adiponectin can lead to muscle wasting which will further reduce body weight and body mass index (BMI), which indirectly also increases the degree of frailty. Until now the relationship between adiponectin with frailty degree in advanced COPD is still unknown.The aims of this study was to investigate the relationship between plasma adiponectin level and frailty in COPD elders. This was an observational analytic cross-sectional study. All anthropometric parameters, including weight, height, and body mass index (BMI), were measured. Adiponectin was measured by ELISA methods obtained from venous blood samples. Aged more than or equal to 60 years old, the patients underwent spirometry to determine the degree of airflow limitation and the degree of frailty defined by the Fried criteria. Statistic analysis used Rank Spearman. Thirty-eight male COPD patients became the subject of the study. The average age was 70-74 years, with a total of 13 robust, 12 prefrails and 13 frail patients. Level of adiponectin (mean and SD) in robust, prefrail, and frail were 6.84+ 2.66 , 6.58 + 4.27, and 11.62 + 4.90 respectively, p=0.015. Further analysis showed that level of adiponectin rose progresively with an increasing number of components of frailty. The degree of obstruction mostly with mild (42.1%), and no subjects with very severe. There were an increase in serum adiponectin levels in all subjects. In conclusion, level of adiponectin serum correlates positively with the degree of frailty.
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