探索草药疗法对COVID-19和流感的影响:研究新兴干预措施的新递送机制

Lucas Fornari Laurindo, Ledyane Taynara Marton, Giulia Minniti, Victória Dogani Rodrigues, Rodrigo Buzinaro Suzuki, Virgínia Maria Cavallari Strozze Catharin, R. Joshi, S. Barbalho
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引用次数: 0

摘要

合成抗病毒药物和皮质类固醇已被用于治疗流感和名为新冠肺炎的SARS-CoV-2疾病。然而,这些药物并不总是有效的,会产生一些不良反应,并且成本高昂。药用植物及其成分作用于流感和新冠肺炎病理生理学中涉及的几种不同靶点和信号通路。本研究旨在评估药用植物对流感和新冠肺炎的影响,并研究新的抗病毒疗法的潜在递送系统。检索EMBASE、PubMed、GOOGLE SCHOLAR和COCHRANE数据库。这篇综述中的研究表明,不同配方的药用植物有助于减少病毒传播和完全康复的时间。植物降低了急性呼吸系统综合征的发病率和疾病的症状评分。此外,植物几乎没有不良影响,而且成本低。除了作为天然抗病毒药物的重要性外,药用植物及其生物活性化合物可能表现出较低的生物利用度。这突出了对替代输送系统的需求,如金属纳米颗粒,它可以有效地将这些化合物输送到受感染的组织。
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Exploring the Impact of Herbal Therapies on COVID-19 and Influenza: Investigating Novel Delivery Mechanisms for Emerging Interventions
Synthetic antivirals and corticosteroids have been used to treat both influenza and the SARS-CoV-2 disease named COVID-19. However, these medications are not always effective, produce several adverse effects, and are associated with high costs. Medicinal plants and their constituents act on several different targets and signaling pathways involved in the pathophysiology of influenza and COVID-19. This study aimed to perform a review to evaluate the effects of medicinal plants on influenza and COVID-19, and to investigate the potential delivery systems for new antiviral therapies. EMBASE, PubMed, GOOGLE SCHOLAR, and COCHRANE databases were searched. The studies included in this review showed that medicinal plants, in different formulations, can help to decrease viral spread and the time until full recovery. Plants reduced the incidence of acute respiratory syndromes and the symptom scores of the illnesses. Moreover, plants are related to few adverse effects and have low costs. In addition to their significance as natural antiviral agents, medicinal plants and their bioactive compounds may exhibit low bioavailability. This highlights the need for alternative delivery systems, such as metal nanoparticles, which can effectively transport these compounds to infected tissues.
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