在啮齿动物行为的实验室研究中考虑生物生理学。

IF 12.1 1区 医学 Q1 NEUROSCIENCES Annual review of neuroscience Pub Date : 2022-04-08 DOI:10.1146/annurev-neuro-111020-085500
Patricia Rubio Arzola, R. Shansky
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引用次数: 1

摘要

在啮齿动物实验室中进行的任何实验都是在实验时每只动物的生理状态的背景下进行的。这种生理状态可以是多种因素的产物,包括内部因素(如动物性别、压力、激素周期或昼夜节律)和外部因素(如住房条件、社会地位和光明/黑暗阶段)。这些因素中的每一个都有可能影响实验结果,无论是独立的还是通过与他人的相互作用,但在实验设计中考虑它们的重量方面,各实验室之间几乎没有一致性。这种实践和报告中的差异可能会导致行为神经科学领域的再现性危机。在这篇综述中,我们讨论了这些可变性的几种来源如何影响共同学习和记忆范式领域的结果。《神经科学年度评论》第45卷预计最终在线出版日期为2022年7月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。
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Considering Organismal Physiology in Laboratory Studies of Rodent Behavior.
Any experiment conducted in a rodent laboratory is done so against the backdrop of each animal's physiological state at the time of the experiment. This physiological state can be the product of multiple factors, both internal (e.g., animal sex, strain, hormone cycles, or circadian rhythms) and external (e.g., housing conditions, social status, and light/dark phases). Each of these factors has the potential to influence experimental outcomes, either independently or via interactions with others, and yet there is little consistency across laboratories in terms of the weight with which they are considered in experimental design. Such discrepancies-both in practice and in reporting-likely contribute to the perception of a reproducibility crisis in the field of behavioral neuroscience. In this review, we discuss how several of these sources of variability can impact outcomes within the realm of common learning and memory paradigms. Expected final online publication date for the Annual Review of Neuroscience, Volume 45 is July 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
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