{"title":"7SK snRNP复合物组装和功能的结构基础","authors":"Aditi N. Borkar, Iván D’Orso","doi":"10.21037/ncri.2018.11.07","DOIUrl":null,"url":null,"abstract":"RNA plays a central role in the precise control of several biological processes including transcription, translation and DNA replication. As such, correct function of RNA-mediated processes is vital for maintaining cell homeostasis thereby avoiding malignancy. The recent structure of human LARP7 and its binding site on 7SK RNA by Feigon and co-workers (1) reveals molecular details into how this protein-RNA interaction contributes to 7SK RNA recognition and provides insights into the assembly of the 7SK small nuclear ribonucleoprotein (snRNP) complex for correct transcriptional control.","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/ncri.2018.11.07","citationCount":"4","resultStr":"{\"title\":\"Structural basis for assembly and function of the 7SK snRNP complex\",\"authors\":\"Aditi N. Borkar, Iván D’Orso\",\"doi\":\"10.21037/ncri.2018.11.07\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"RNA plays a central role in the precise control of several biological processes including transcription, translation and DNA replication. As such, correct function of RNA-mediated processes is vital for maintaining cell homeostasis thereby avoiding malignancy. The recent structure of human LARP7 and its binding site on 7SK RNA by Feigon and co-workers (1) reveals molecular details into how this protein-RNA interaction contributes to 7SK RNA recognition and provides insights into the assembly of the 7SK small nuclear ribonucleoprotein (snRNP) complex for correct transcriptional control.\",\"PeriodicalId\":74314,\"journal\":{\"name\":\"Non-coding RNA investigation\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-11-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.21037/ncri.2018.11.07\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Non-coding RNA investigation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21037/ncri.2018.11.07\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Non-coding RNA investigation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21037/ncri.2018.11.07","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Structural basis for assembly and function of the 7SK snRNP complex
RNA plays a central role in the precise control of several biological processes including transcription, translation and DNA replication. As such, correct function of RNA-mediated processes is vital for maintaining cell homeostasis thereby avoiding malignancy. The recent structure of human LARP7 and its binding site on 7SK RNA by Feigon and co-workers (1) reveals molecular details into how this protein-RNA interaction contributes to 7SK RNA recognition and provides insights into the assembly of the 7SK small nuclear ribonucleoprotein (snRNP) complex for correct transcriptional control.
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