5-氨基-N-取代吡唑作为生物活性分子构建基的综述

W. A. Bawazir
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引用次数: 1

摘要

在这篇综述中,一种具有两个相邻氮原子的五元杂环被称为吡唑,我们构建了5-氨基-N-取代的吡唑,特别关注其作为构建块和生产巨大杂环骨架的起始材料的重要作用。该部分在较大化合物中的存在使它们暴露出药用、药理学和生物治疗活性。大量药物含有5-氨基-N-取代吡唑,如塞来昔布抗炎药、抗精神病药、抗肥胖药、镇痛药和抗抑郁药。我们报道了这些化合物的各种合成途径和用途。
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A Mini-Review 5-Amino-N-Substituted Pyrazoles as Building Blocks for Bioactive Molecules
In this review a five-membered heterocyclic ring having two adjacent nitrogen atoms known as Pyrazole, we have framed 5-amino-N-substituted pyrazoles in particular focusing on its substantial role as a building block and starting materials for producing enormous heterocyclic skeletons. The existence of this moiety in larger compounds renders them to expose medicinal, pharmacological and biological therapeutic activities. Enormous drugs contain 5-amino-N-substituted pyrazoles such as celecoxib anti-inflammatory, antipsychotic, anti-obesity, analgesic, and antidepressant. We reported various routes of synthesis and the use of these compounds.
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