脂质改性剂全球和国内市场评估:回顾与创新

Q4 Biochemistry, Genetics and Molecular Biology Sibirskii nauchnyi meditsinskii zhurnal Pub Date : 2023-08-29 DOI:10.18699/ssmj20230403
A. V. Lokhmacheva, S. G. Fominykh, L. V. Trubina, I. E. Sikhvardt
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引用次数: 0

摘要

降脂治疗是心血管疾病患者治疗中最重要的方面之一,心血管疾病仍然是成年人群死亡的主要原因。在过去的10年里,出现了一些全新的降脂药物,如阿脂基因-替帕沃韦克、米波默森、洛米他吡、埃沃洛单抗、阿罗库单抗、贝贝二酸、包括利西兰、埃维那单抗、沃兰索森。为了更新有关降脂药物使用的有效性和安全性的信息,回顾过去和目前,在科学数据库eLIBRARY.RU、PubMed、Embase、ClinicalTrials.gov、Cochrane图书馆、俄罗斯国家药品登记册中进行了系统搜索,时间为1980年至2023年。他汀类药物仍然是经常使用的主要药物,违反了脂质代谢。纤维是罕见的高甘油三酯血症患者的首选药物。从作用机制、使用适应症以及俄罗斯联邦和世界注册证书的可用性的角度,对一组其他降脂药物进行了表征。作为进口替代战略的一部分,当地公司在其生产中所占份额的高增长证实了俄罗斯制药市场对依折麦布日益增长的兴趣。已经证实,作为联合治疗的一部分,该药物引起不良影响的可能性很小。前蛋白转化酶枯草杆菌蛋白酶可新9型抑制剂(PCSK9)为治疗心血管疾病高危患者开辟了新的可能性。洛米他匹德未在俄罗斯联邦注册,但自2021年12月以来,它已被列入克鲁格-多布拉基金会购买的药物清单,以帮助患有纯合性家族性高胆固醇血症的儿童。自2022年以来,inclisiran,一种通过RNA干扰抑制PCSK9合成的药物,已被批准在俄罗斯使用,对高脂血症和他汀类药物不耐受患者是安全的。因此,在21世纪,降脂药物出现了根本性的新位置,这是生物技术和基因治疗药物的例子。
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Assessment of the global and national market for lipid modifying agents: retrospective and innovation
Lipid-lowering therapy is one of the most important aspects in the treatment of patients with cardiovascular disease, which is still the leading cause of death in the adult population. Over the past 10 years, fundamentally new lipid-lowering drugs have appeared such as alipogene tiparvovec, mipomersen, lomitapide, evolocumab, alirocumab, bempedoic acid, inclisiran, evinacumab, volanesorsen. In order to update information on the effectiveness and safety of the use of lipidlowering drugs, their consumption in the pharmaceutical market in retrospect and at the present time, a systematic search was carried out in the scientific databases eLIBRARY.RU, PubMed, Embase, ClinicalTrials.gov, the Cochrane Library, Russian State Register of Medicines from 1980 to 2023. Statins remain the main drugs of choice for regular use in violation of lipid metabolism. Fibrates are the drugs of choice in patients with rare forms of hyperlipidemia associated with high triglyceride level. A group of other lipid-lowering drugs has been characterized from the point of view of the mechanisms of action, indications for use, and the availability of registration certificates in the Russian Federation and in the world. The growing interest in ezetimibe in the Russian pharmaceutical market is confirmed by the high growth in the share of local companies in its production as part of the import substitution strategy. It has been established that the drug causes undesirable effects with a small degree of probability as part of combination therapy. Inhibitors of proprotein convertase subtilisin-kexin type 9 (PCSK9) open up new possibilities for the treatment of patients at very high risk of cardiovascular disease. Lomitapide is not registered in the Russian Federation, but since December 2021 it has been included in the list of medicines purchased by the Krug Dobra Foundation to help children with homozygous familial hypercholesterolemia. Since 2022, inclisiran, a drug inhibiting synthesis of PCSK9 with RNA interference, has been approved for use in Russia and is safe in patients with hyperlipidemia and statin intolerance. Thus, in the 21st century, fundamentally new positions have appeared in the group of lipid-lowering drugs, which are examples of biotechnological and gene therapy drugs.
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来源期刊
CiteScore
0.40
自引率
0.00%
发文量
54
审稿时长
12 weeks
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