Yi Yan, Zhao Yong, Li Chunying, Zhang Yushi, Bin Yang, Yuan Yalan, Pan Chen, Wang Lianmei, Liang Aihua
{"title":"黄芩乙醇提取物对大鼠慢性肝毒性的潜在影响","authors":"Yi Yan, Zhao Yong, Li Chunying, Zhang Yushi, Bin Yang, Yuan Yalan, Pan Chen, Wang Lianmei, Liang Aihua","doi":"10.1016/j.jtcm.2017.05.002","DOIUrl":null,"url":null,"abstract":"<div><h3>OBJECTIVE</h3><p>To investigate the potential chronic liver toxicity of oral administration of ethanol extract of Huangqin (<em>Radix Scutellariae Baicalensis</em>) (SBE) in Wistar rats.</p></div><div><h3>METHODS</h3><p>SBE was administered to rats by gavage for 26 weeks, at doses of 300, 1250, or 2500 mg•kg<sup>−1</sup>•d<sup>−1</sup> respectively. The rats were euthanized at the end of 13 and 26 weeks daily oral dosing and following 4 weeks of recovery time. The changes of hematology, urinary, blood biochemistry and histomorphology were examined at each time point and focus on liver function and histological changes.</p></div><div><h3>RESULTS</h3><p>When SBE at a dose of up to 2500 mg•kg<sup>−1</sup>•d<sup>−1</sup> was fed to male and female rats for 26 weeks, the liver tissue showed some inflammatory change that predominated by leukocyte infiltration but returned to normal after withdrawal. In addition, high-dose SBE treatment of 26 weeks in rats, glucose, electrolyte and lipid levels also have some changes. In addition, there are no other functional or organic lesions related to SBE treatment.</p></div><div><h3>CONCLUSIONS</h3><p>Long-term and high-dose SBE may cause liver damage, however, the structural damage of the liver can be restored after the ethanol extract stopping. SBE will be well-tolerated for long-term use as a drug or health food, but in order to ensure drug safety, liver function, and serum glucose, electrolyte and lipid levels should be monitored when using SBE long term.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 2","pages":"Pages 242-256"},"PeriodicalIF":2.0000,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jtcm.2017.05.002","citationCount":"12","resultStr":"{\"title\":\"Potential chronic liver toxicity in rats orally administered an ethanol extract of Huangqin (Radix Scutellariae Baicalensis)\",\"authors\":\"Yi Yan, Zhao Yong, Li Chunying, Zhang Yushi, Bin Yang, Yuan Yalan, Pan Chen, Wang Lianmei, Liang Aihua\",\"doi\":\"10.1016/j.jtcm.2017.05.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>OBJECTIVE</h3><p>To investigate the potential chronic liver toxicity of oral administration of ethanol extract of Huangqin (<em>Radix Scutellariae Baicalensis</em>) (SBE) in Wistar rats.</p></div><div><h3>METHODS</h3><p>SBE was administered to rats by gavage for 26 weeks, at doses of 300, 1250, or 2500 mg•kg<sup>−1</sup>•d<sup>−1</sup> respectively. The rats were euthanized at the end of 13 and 26 weeks daily oral dosing and following 4 weeks of recovery time. The changes of hematology, urinary, blood biochemistry and histomorphology were examined at each time point and focus on liver function and histological changes.</p></div><div><h3>RESULTS</h3><p>When SBE at a dose of up to 2500 mg•kg<sup>−1</sup>•d<sup>−1</sup> was fed to male and female rats for 26 weeks, the liver tissue showed some inflammatory change that predominated by leukocyte infiltration but returned to normal after withdrawal. In addition, high-dose SBE treatment of 26 weeks in rats, glucose, electrolyte and lipid levels also have some changes. In addition, there are no other functional or organic lesions related to SBE treatment.</p></div><div><h3>CONCLUSIONS</h3><p>Long-term and high-dose SBE may cause liver damage, however, the structural damage of the liver can be restored after the ethanol extract stopping. SBE will be well-tolerated for long-term use as a drug or health food, but in order to ensure drug safety, liver function, and serum glucose, electrolyte and lipid levels should be monitored when using SBE long term.</p></div>\",\"PeriodicalId\":17513,\"journal\":{\"name\":\"Journal of Traditional Chinese Medicine\",\"volume\":\"38 2\",\"pages\":\"Pages 242-256\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2018-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.jtcm.2017.05.002\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Traditional Chinese Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S025462721830267X\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INTEGRATIVE & COMPLEMENTARY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Traditional Chinese Medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S025462721830267X","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
Potential chronic liver toxicity in rats orally administered an ethanol extract of Huangqin (Radix Scutellariae Baicalensis)
OBJECTIVE
To investigate the potential chronic liver toxicity of oral administration of ethanol extract of Huangqin (Radix Scutellariae Baicalensis) (SBE) in Wistar rats.
METHODS
SBE was administered to rats by gavage for 26 weeks, at doses of 300, 1250, or 2500 mg•kg−1•d−1 respectively. The rats were euthanized at the end of 13 and 26 weeks daily oral dosing and following 4 weeks of recovery time. The changes of hematology, urinary, blood biochemistry and histomorphology were examined at each time point and focus on liver function and histological changes.
RESULTS
When SBE at a dose of up to 2500 mg•kg−1•d−1 was fed to male and female rats for 26 weeks, the liver tissue showed some inflammatory change that predominated by leukocyte infiltration but returned to normal after withdrawal. In addition, high-dose SBE treatment of 26 weeks in rats, glucose, electrolyte and lipid levels also have some changes. In addition, there are no other functional or organic lesions related to SBE treatment.
CONCLUSIONS
Long-term and high-dose SBE may cause liver damage, however, the structural damage of the liver can be restored after the ethanol extract stopping. SBE will be well-tolerated for long-term use as a drug or health food, but in order to ensure drug safety, liver function, and serum glucose, electrolyte and lipid levels should be monitored when using SBE long term.
期刊介绍:
Journal of Traditional Chinese Medicine(JTCM) is devoted to clinical and theortical research on the use of acupuncture and Oriental medicine. The main columns include Clinical Observations, Basic Investigations, Reviews, Questions and Answers, an Expert''s Forum, and Discussions of Clinical Cases. Its key topics include acupuncture and electro-acupuncture, herbal medicine, homeopathy, masseotherapy, mind-body therapies, palliative care, and other CAM therapies.