基于脂蛋白偶联物的递送系统在营养、药物和基因递送中的最新进展

IF 4.6 Q1 CHEMISTRY, APPLIED Food Hydrocolloids for Health Pub Date : 2022-12-01 DOI:10.1016/j.fhfh.2022.100054
Thilini Dissanayake , Xiaohong Sun , Lord Abbey , Nandika Bandara
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引用次数: 8

摘要

长期以来,脂质和蛋白质为基础的输送系统一直被用于输送活性化合物,如药物、基因和营养保健品。这些输送系统是为了克服纯活性化合物的问题而制造的,这些问题包括快速释放和代谢,溶解度差,稳定性低,生物利用度差,生物可及性差以及毒性。然而,脂质和蛋白质的局限性限制了它们在输送系统中的有效利用。脂质-蛋白偶联是一种用于制造新型递送系统的新兴技术,它提供了在一个递送系统中同时具有蛋白质和脂质的优点。此外,这些缀合物在体内具有比单一载体更好的协同作用和理想的性质。其中,胶体和生物稳定性、机械强度增强、控释、循环时间延长、靶向给药、细胞毒性降低、负载能力提高、共包封和生物利用度增强是关键成果。尽管最近的技术进步,仍有缺陷的脂蛋白缀合物为基础的递送系统,应在未来的研究中解决。本文将重点评价脂质和蛋白质作为传递系统的重要性,脂质-蛋白质偶联的益处,偶联方法,脂质-蛋白质偶联在药物,基因和营养食品传递中的各种应用,并确定研究挑战和未来的研究方向。
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Recent advances in lipid-protein conjugate-based delivery systems in nutraceutical, drug, and gene delivery

Lipid and protein-based delivery systems have long been used to deliver active compounds such as drugs, genes, and nutraceuticals. These delivery systems are fabricated to overcome issues of pure active compounds, which include rapid release and metabolism, poor solubility, low stability, poor bioavailability, poor bioaccessibility, and toxicity. However, there are limitations of lipids and proteins that restrict their efficient use in the delivery systems. Lipid-protein conjugation is an emerging technique for fabricating novel delivery systems that provide the advantages of having both proteins and lipids in one delivery system. In addition, these conjugates have a much better synergistic effect and desirable properties inside the body than single carriers. Among them, colloidal and biological stability, enhanced mechanical strength, controlled release, higher circulation time, targeted delivery, less cytotoxicity, higher loading capacity, co-encapsulation, and enhanced bioavailability are key outcomes. Despite recent technological advancement, there are still drawbacks to lipid-protein conjugate-based delivery systems that should be addressed in future research studies. This review is focused on critically evaluating the importance of lipid and protein as delivery systems, benefits of lipid-protein conjugation, conjugation methods, various applications of lipid-protein conjugation in drugs, genes, and nutraceutical delivery, and identifying research challenges and future research directions.

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