血清新蝶呤及其生物标志物在脓毒症Mods鉴别中的意义

IF 0.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pteridines Pub Date : 2018-12-31 DOI:10.1515/pteridines-2018-0018
Xiaohong Zhang, Qingli Chen, Shuang Ni, Zemin Xiang, Xiaohui Zhou, Yuanyuan Huang
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引用次数: 2

摘要

摘要目的探讨血清新蝶呤的动态变化及其作为MODS与败血症鉴别诊断生物标志物的意义。方法对58例危重症患者和21例健康对照进行研究。在纳入的58名危重症患者中,37例被诊断为败血症(败血症组),其他21例为非败血症受试者(非败血症组)。在37例败血症患者中,17例被诊断为多器官功能障碍综合征(MODS组)。采用酶联免疫吸附法检测上述受试者的血清新蝶呤水平,并在各组之间进行比较。结果健康对照组、非脓毒症组、非MODS组和MODS组血清新蝶呤水平分别为0.885±0.34(ng/mL)、3.77±2.08(ng/mL,以血清新蝶呤作为MODS与脓毒症鉴别的生物标志物,其诊断敏感性、特异性和AUC分别为70.59%(95%CI:44.04-89.69)%、80.00%(95%CI:56.34-94.27)%和0.74(95%CI:0.57-0.91)%。结论脓毒症患者血清新蝶呤水平升高,可作为鉴别MODS与脓毒症的一种有前景的生物标志物。
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Serum Neopterin and its Significance as Biomarker in Differentiation of Mods From Sepsis
Abstract Objective The aim of this study was to evaluate the dynamic changes of serum neopterin and its significance as biomarker in differentiation of MODS from sepsis. Methods Fifty eight critical illness patients and 21 healthy controls were included in the study. Of the included 58 critical illness patients, 37 cases were diagnosed of sepsis (sepsis group) and other 21 were non-sepsis subjects (non-sepsis group). Of the 37 sepsis patients, 17 were diagnosed of multiple organ dysfunction syndrome (MODS group). The serum level of neopterin of the above subjects were examined by enzyme linked immunosorbent assay and compared between groups. Results The serum level of neopterin were 0.885±0.34(ng/mL), 3.77±2.08(ng/mL), 14.80±6.78(ng/mL) and 23.90±11.26(ng/mL) for healthy control, non-sepsis, non-MODS and MODS groups respectively with significant statistical difference (F=52.71, p<0.001). Serum neopterin level of non-sepsis, non-MODS and MODS groups were statistical different in the time points of 0, 24h, 48h, 72h, and 96h (p<0.05). The serum neopterin level was significant higher in MODS group compared to nonsepsis and non-MODS groups (p<0.05). Using the serum neopterin as biomarker in differentiation of MODS from sepsis, the diagnostic sensitivity, specificity and AUC were 70.59% (95%CI:44.04-89.69) %, 80.00% (95%CI:56.34- 94.27)% and 0.74(95%CI:0.57-0.91)% respectively. Conclusion Serum neopterin levels in patients with sepsis were elevated and can be used as a promising biomarker in differentiation of MODS from sepsis.
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来源期刊
Pteridines
Pteridines 生物-生化与分子生物学
CiteScore
1.20
自引率
25.00%
发文量
6
审稿时长
>12 weeks
期刊介绍: Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.
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