HIV/AIDS孕妇母婴阻断前后相关实验室检测指标的研究进展

Guosheng Su, L. Qin, Lida Mo
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引用次数: 0

摘要

90%以上的HIV阳性儿童来自母婴传播,因此母婴阻断是预防儿童艾滋病的主要措施。相关数据显示,在没有干预的情况下,艾滋病毒母婴传播的发生率通常在15%至50%之间波动。规范有效的综合干预可以将母婴传播率降低到1%以下。目前,人们认为艾滋病的母婴传播可以通过综合干预来阻断,其机制已经得到了明确的研究。结合高效的抗病毒治疗、安全分娩和人工喂养,母婴传播率可以降低到1%以下。然而,由于药物对艾滋病母婴传播的影响可能会导致母婴主要生化指标发生一些变化,目前还没有系统分析艾滋病母婴传播前后孕妇的病毒载量、T淋巴细胞亚群和主要生化指标。本研究对母婴阻断前后HIV/AIDS孕妇的病毒载量、T淋巴细胞亚群及主要生化指标进行了动态分析。希望这项研究将有助于观察感染艾滋病毒/艾滋病的孕妇在怀孕期间的基本身体素质和疾病发展情况,为母婴阻断治疗和评估艾滋病毒/艾滋病孕妇提供有力的依据,并建立一套完整的实验室指标,了解孕妇各阶段的身体状况,最大限度地降低胎儿传播的概率,将产生良好的经济效益和社会效益。
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Research Progress of Related Laboratory Testing Indexes before and after Mother-Infant Blocking in HIV/AIDS Pregnant Women
More than 90% of HIV-positive children come from mother-to-child transmission, so mother-to-child interdiction is the main measure to prevent AIDS in children. Relevant data show that the incidence of mother-to-child transmission of HIV usually fluctuates between 15% and 50% without intervention. Standardized and effective comprehensive intervention can reduce the transmission rate of mother to child to less than 1%. At present, it is believed that mother-to-child transmission of AIDS can be blocked by comprehensive intervention, and its mechanism has been clearly studied. Combined with highly effective antiviral treatment, safe labor and artificial feeding, the mother to child transmission rate can be reduced to less than 1%. However, due to the effect of drugs on mother-to-child transmission of AIDS may lead to some changes in the main biochemical indicators of mother-to-child, there is no systematic analysis of the viral load, T lymphocyte subsets and major biochemical indicators of HIV/AIDS pregnant women before and after maternal-to-child transmission. In this study, the viral load, T lymphocyte subsets and major biochemical indicators of HIV/AIDS pregnant women before and after maternal-infant blockade were dynamically analyzed. It is hoped that this study will help to observe the basic physical fitness and disease development of pregnant women with HIV/AIDS during pregnancy, to provide a strong basis for the treatment and evaluation of maternal-infant blockade of HIV/AIDS pregnant women, and to establish a complete set of laboratory indicators to understand the body status of pregnant women at all stages to minimize the probability of fetal transmission, which will make good economic and social benefits.
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