MOG antibody associated with central and peripheral demyelination

MOG antibody disorder presenting as a combined central and peripheral demyelination (CCPD) is uncommon. CCPD has been associated with other primary demyelination syndromes such as multiple sclerosis, neuromyelitis optica or chronic inflammatory demyelinating polyneuropathy. Here, the authors describe the diagnosis and management of a 21‐year‐old female with historically sequential demyelinating plaques in her right thalamus, cervical cord, left optic nerve and electrophysiology suggestive of bilateral ulnar nerve demyelination.