{"title":"补充维生素D3联合标准化降糖方案对新诊断2型糖尿病胰岛β细胞功能及大血管并发症的影响","authors":"Shiwei Liu, Ruixue Duan, Xin Li, Jiaxin Zhang, Yaru Wu","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.06.005","DOIUrl":null,"url":null,"abstract":"Objective \nTo investigate the effects of vitamin D3 supplementation combined with standardized hypoglycemic regimen on islet β cell function and macroangiopathy of T2DM patients. \n \n \nMethods \nA total of 192 patients with type 2 diabetes mellitus were selected and randomly divided into control group and observation group with 96 patients in each group. Patients in two groups were given standardized hypoglycemic regimen, and the observation group was treated with vitamin D3 supplementation in addition. The changes of the indexes of body examination, glycolipid metabolism, islet β cell function and macrovascular complications before and 6 months after treatment were compared between the two groups. \n \n \nResults \nAfter 6 months of treatment, BMI, SBP, TG, FBG, FINS, HbA1c and HOMA-IR decreased, while HOMA-β increased in both groups (P<0.05). Compared with the control group, the serum levels of 25 (OH) D increased, and vaspin and CRP decreased significantly after 6 months of treatment in the observation group (P<0.05). CIMT and other indicators showed no significant difference. 25 (OH) D was negatively correlated with FBG, FINS, vaspin and CRP, and positively correlated with 1PH and ISI (P<0.05). \n \n \nConclusion \nVitamin D3 is closely related to T2DM and its macrovascular complications, but it has not been found that vitamin D3 supplementation can further improve islet β cell function and macrovascular complications in patients with T2DM. \n \n \nKey words: \nType 2 diabetes; Vitamin D; Islet Cell Function; Macroangiopathy; Vaspin","PeriodicalId":9877,"journal":{"name":"中华临床营养杂志","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of vitamin D3 supplementation combined with standardized hypoglycemic regimen on islet β cell function and macrovascular complications in newly diagnosed type 2 diabetes mellitus\",\"authors\":\"Shiwei Liu, Ruixue Duan, Xin Li, Jiaxin Zhang, Yaru Wu\",\"doi\":\"10.3760/CMA.J.ISSN.1674-635X.2019.06.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo investigate the effects of vitamin D3 supplementation combined with standardized hypoglycemic regimen on islet β cell function and macroangiopathy of T2DM patients. \\n \\n \\nMethods \\nA total of 192 patients with type 2 diabetes mellitus were selected and randomly divided into control group and observation group with 96 patients in each group. Patients in two groups were given standardized hypoglycemic regimen, and the observation group was treated with vitamin D3 supplementation in addition. The changes of the indexes of body examination, glycolipid metabolism, islet β cell function and macrovascular complications before and 6 months after treatment were compared between the two groups. \\n \\n \\nResults \\nAfter 6 months of treatment, BMI, SBP, TG, FBG, FINS, HbA1c and HOMA-IR decreased, while HOMA-β increased in both groups (P<0.05). Compared with the control group, the serum levels of 25 (OH) D increased, and vaspin and CRP decreased significantly after 6 months of treatment in the observation group (P<0.05). CIMT and other indicators showed no significant difference. 25 (OH) D was negatively correlated with FBG, FINS, vaspin and CRP, and positively correlated with 1PH and ISI (P<0.05). \\n \\n \\nConclusion \\nVitamin D3 is closely related to T2DM and its macrovascular complications, but it has not been found that vitamin D3 supplementation can further improve islet β cell function and macrovascular complications in patients with T2DM. \\n \\n \\nKey words: \\nType 2 diabetes; Vitamin D; Islet Cell Function; Macroangiopathy; Vaspin\",\"PeriodicalId\":9877,\"journal\":{\"name\":\"中华临床营养杂志\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-12-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华临床营养杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.06.005\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Nursing\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华临床营养杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.06.005","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Nursing","Score":null,"Total":0}
Effects of vitamin D3 supplementation combined with standardized hypoglycemic regimen on islet β cell function and macrovascular complications in newly diagnosed type 2 diabetes mellitus
Objective
To investigate the effects of vitamin D3 supplementation combined with standardized hypoglycemic regimen on islet β cell function and macroangiopathy of T2DM patients.
Methods
A total of 192 patients with type 2 diabetes mellitus were selected and randomly divided into control group and observation group with 96 patients in each group. Patients in two groups were given standardized hypoglycemic regimen, and the observation group was treated with vitamin D3 supplementation in addition. The changes of the indexes of body examination, glycolipid metabolism, islet β cell function and macrovascular complications before and 6 months after treatment were compared between the two groups.
Results
After 6 months of treatment, BMI, SBP, TG, FBG, FINS, HbA1c and HOMA-IR decreased, while HOMA-β increased in both groups (P<0.05). Compared with the control group, the serum levels of 25 (OH) D increased, and vaspin and CRP decreased significantly after 6 months of treatment in the observation group (P<0.05). CIMT and other indicators showed no significant difference. 25 (OH) D was negatively correlated with FBG, FINS, vaspin and CRP, and positively correlated with 1PH and ISI (P<0.05).
Conclusion
Vitamin D3 is closely related to T2DM and its macrovascular complications, but it has not been found that vitamin D3 supplementation can further improve islet β cell function and macrovascular complications in patients with T2DM.
Key words:
Type 2 diabetes; Vitamin D; Islet Cell Function; Macroangiopathy; Vaspin