部分二氧化碳激光辅助阿莫罗芬与阿莫罗芬单独给药治疗甲真菌病的随机比较研究

Prateek Sharma, Niti Khunger
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引用次数: 1

摘要

目的比较部分二氧化碳(CO2)激光辅助阿莫洛芬和阿莫洛芬单独局部治疗甲真菌病的临床有效率、患者满意度和副作用。患者和方法总共招募了100名患者进行研究,并根据抽签系统将其分为两组。第1组(50名患者)接受部分CO2激光和局部阿莫洛芬(5%)的联合治疗,第2组(n=50)接受5%阿莫洛芬单独治疗。通过比较基线和最后一次治疗后12周的感染面积,使用临床检查、甲镜检查模式和真菌学清除率来确定总体治疗效果。结果与第2组相比,第1组的临床有效率显著高于第2组(22%对0%,P<0.0001)。第1组患者的满意度也较高(64%对6%,P<0.001)。副作用中,第一组患者出现轻微疼痛,第2组患者无疼痛。结论部分CO2激光辅助局部应用阿莫罗芬(5%)治疗甲真菌病的疗效优于单独应用阿莫罗芬。可以通过标准化参数和会话次数来进一步探索部分CO2激光器的使用,以实现更好的治愈率,从而可以取代全身治疗。
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A randomized comparative study of fractional carbon dioxide laser-assisted drug delivery with amorolfine versus amorolfine alone for the treatment of onychomycosis
Objective The study was done to compare the clinical efficacy rate, patient satisfaction, and side effects of fractional carbon dioxide (CO2) laser-assisted topical therapy with amorolfine versus amorolfine alone for the treatment of onychomycosis. Patients and methods In all, 100 patients were recruited for the study and were divided based on the lottery system into two groups. Group 1 (50 patients) received a combination of fractional CO2 laser and topical amorolfine (5%) and group 2 (n=50) received 5% amorolfine alone. The overall treatment efficacy was determined using clinical examination, onychoscopic pattern, and mycological clearance by comparing the infected area at baseline and 12 weeks after last treatment. Results Compared with group 2, clinical efficacy rate was significantly more in group 1 (22 vs. 0%, P<0.0001). Patient satisfaction rate was also higher in group 1 (64 vs. 6%, P<0.0001). Among the side-effects, mild pain was noted in group 1 with none in group 2 patients. Conclusion Fractional CO2 laser-assisted delivery of topical amorolfine (5%) therapy of onychomycosis showed a better clinical response than topical amorolfine (5%) alone. Fractional CO2 lasers may be explored further for use by standardizing the parameters and number of sessions to achieve better cure rates and thereby can replace systemic treatment.
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