Samy Hanafy, T. Mostafa, Heba Abd-Elhameed, L. Rashed, E. M. Akl
Varicocele is considered a common and correctable cause of male infertility. This is established by the improvement of sperm parameters after surgical correction. Endoglin (Eng) is presented in two forms, a membrane and soluble forms, and the equilibrium between these forms depends on the oxidative status. Eng is linked to several pathological conditions common in varicocele as hypoxia and apoptosis. This study aimed to evaluate the seminal level of soluble Eng in infertile oligoasthenoteratozoospermic (OAT) men associated with varicocele. Sixty men were enrolled in this study. They were divided into two groups: infertile OAT men with varicocele and healthy fertile men as a control group. These participants were subjected to complete history taking, clinical and genital examination, semen analysis, and assessment of soluble Eng pre- and 6 months after the surgical intervention. The results showed a significant elevation of seminal soluble Eng in infertile OAT men associated with varicocele than in fertile control. Six months postsurgical correction, there was a significant improvement in semen parameters accompanied by a significant decrease in the seminal level of soluble Eng. It was concluded that seminal soluble Eng is elevated in infertile OAT men linked to varicocele concurrent with the negative effect on sperm parameters. The surgical correction of varicocele in these cases shows significant improvement in these criteria.
精索静脉曲张被认为是导致男性不育的一个常见且可矫正的原因。手术矫正后精子参数的改善证明了这一点。内胚层蛋白（Eng）有两种形式，一种是膜形式，另一种是可溶性形式，这两种形式之间的平衡取决于氧化状态。Eng与精索静脉曲张常见的几种病理情况有关，如缺氧和细胞凋亡。 本研究旨在评估伴有精索静脉曲张的不育少精症（OAT）男性精液中可溶性 Eng 的水平。 本研究共招募了 60 名男性。他们被分为两组：患有精索静脉曲张的不育 OAT 男性和作为对照组的健康可育男性。这些参与者接受了完整的病史采集、临床和生殖器检查、精液分析以及手术前和手术后 6 个月的可溶性 Eng 评估。 结果显示，与可育对照组相比，患有精索静脉曲张的 OAT 不育男性精液可溶性 Eng 明显升高。手术矫正 6 个月后，精液参数明显改善，同时精液中可溶性 Eng 水平显著下降。 结论是，与精索静脉曲张有关的 OAT 不育男性精液中可溶性 Eng 升高，同时对精子参数产生负面影响。对这些病例进行精索静脉曲张手术矫正后，这些指标均有明显改善。
{"title":"Seminal Endoglin in infertile men with varicocele, a cohort study","authors":"Samy Hanafy, T. Mostafa, Heba Abd-Elhameed, L. Rashed, E. M. Akl","doi":"10.4103/ejdv.ejdv_46_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_46_23","url":null,"abstract":"\u0000 \u0000 Varicocele is considered a common and correctable cause of male infertility. This is established by the improvement of sperm parameters after surgical correction. Endoglin (Eng) is presented in two forms, a membrane and soluble forms, and the equilibrium between these forms depends on the oxidative status. Eng is linked to several pathological conditions common in varicocele as hypoxia and apoptosis.\u0000 \u0000 \u0000 \u0000 This study aimed to evaluate the seminal level of soluble Eng in infertile oligoasthenoteratozoospermic (OAT) men associated with varicocele.\u0000 \u0000 \u0000 \u0000 Sixty men were enrolled in this study. They were divided into two groups: infertile OAT men with varicocele and healthy fertile men as a control group. These participants were subjected to complete history taking, clinical and genital examination, semen analysis, and assessment of soluble Eng pre- and 6 months after the surgical intervention.\u0000 \u0000 \u0000 \u0000 The results showed a significant elevation of seminal soluble Eng in infertile OAT men associated with varicocele than in fertile control. Six months postsurgical correction, there was a significant improvement in semen parameters accompanied by a significant decrease in the seminal level of soluble Eng.\u0000 \u0000 \u0000 \u0000 It was concluded that seminal soluble Eng is elevated in infertile OAT men linked to varicocele concurrent with the negative effect on sperm parameters. The surgical correction of varicocele in these cases shows significant improvement in these criteria.\u0000","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140687322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Doaa D. Mohamed, H. Mahrous, Hany Khalil, Ibrahim A. Ibrahim, Dalia D. Mohamed, Omar S. Keshk, Alaa H. Nada, A. I. Maksoud
Skin cancer accounts for most malignancies across the globe. They are primarily divided into melanoma and nonmelanoma skin malignancies. Nonmelanoma skin cancer includes basal cell carcinoma and squamous cell carcinoma. Glycyrrhetinic acid (GA) is a bioactive compound extracted from licorice that exhibits an inhibition effect on various cancers. GA has been reported to have in vitro cytotoxic effects on several human cancer cells. However, reports on the mode of action and detailed mechanism of GA in vitro in skin cancer disease are limited. Hence, GA’s effect on the human skin cell line BJ and MCC13 was investigated. MTT assay showed that GA had cytotoxic effects on MCC13 cells but was non-toxic to the normal cells of BJ in a time-dose dependent manner. GA also inhibited the angiogenic sprouting of new blood vessels in tumor progression. In gene expression assay, GA induces mitochondrial apoptosis through the induction and inhibition of Cytochrome C and Bcl2 respectively. In conclusion, GA is a potent candidate to induce apoptosis and concurrently inhibit the invasion, migration, and angiogenesis of the MCC13 cell line through increasing TNF-alpha concentration resulting in the necroptotic pathway induction.
{"title":"Regulation of angiogenesis and inflammatory pathways by glycyrrhizic acid","authors":"Doaa D. Mohamed, H. Mahrous, Hany Khalil, Ibrahim A. Ibrahim, Dalia D. Mohamed, Omar S. Keshk, Alaa H. Nada, A. I. Maksoud","doi":"10.4103/ejdv.ejdv_39_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_39_23","url":null,"abstract":"Skin cancer accounts for most malignancies across the globe. They are primarily divided into melanoma and nonmelanoma skin malignancies. Nonmelanoma skin cancer includes basal cell carcinoma and squamous cell carcinoma. Glycyrrhetinic acid (GA) is a bioactive compound extracted from licorice that exhibits an inhibition effect on various cancers. GA has been reported to have in vitro cytotoxic effects on several human cancer cells. However, reports on the mode of action and detailed mechanism of GA in vitro in skin cancer disease are limited. Hence, GA’s effect on the human skin cell line BJ and MCC13 was investigated. MTT assay showed that GA had cytotoxic effects on MCC13 cells but was non-toxic to the normal cells of BJ in a time-dose dependent manner. GA also inhibited the angiogenic sprouting of new blood vessels in tumor progression. In gene expression assay, GA induces mitochondrial apoptosis through the induction and inhibition of Cytochrome C and Bcl2 respectively. In conclusion, GA is a potent candidate to induce apoptosis and concurrently inhibit the invasion, migration, and angiogenesis of the MCC13 cell line through increasing TNF-alpha concentration resulting in the necroptotic pathway induction.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140689400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Loss of follow-up of HIV patients from an HIV clinic during COVID-19 outbreak period: what are the reasons?","authors":"P. Sookaromdee, V. Wiwanitkit","doi":"10.4103/ejdv.ejdv_27_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_27_23","url":null,"abstract":"","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140688319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jigna Patel, Dharmender Jairam, Kajal G. Kansara, Tejasvi Patel, Bela J. Shah
Langerhans cell histiocytosis (LCH), previously known as histiocytosis X, is an idiopathic uncommon haematological condition affecting infants and young children but can occur at any age group characterized by clonal proliferation of abnormal Langerhans cells. Langerhans cells express an immunophenotype positive for S100 protein, CD1a and Langerin (CD207). Here we present a case of 2-year-old male patient presented with a multiple raw area associated with oozing, bleeding and crusted lesions were present over scalp, trunk and post-auricular areas. Radiographic examination revealed multiple osteolytic bone involvement. Histopathological examination revealed Langerhans cell histiocytosis. Immunophenotyping was positive for vimentin, CD1a, and S100. Based on radiological, histological and immunophenotyping findings suggestive of multisystem LCH. The purpose of this report is to describe a rare case of LCH in the 2-year-old male child with multisystem LCH involving skin, soft tissue and bones and to discuss clinical, radiological and histopathological features of LCH.
{"title":"Letterer–Siwe disease: a case of multisystem Langerhans cell histiocytosis","authors":"Jigna Patel, Dharmender Jairam, Kajal G. Kansara, Tejasvi Patel, Bela J. Shah","doi":"10.4103/ejdv.ejdv_18_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_18_23","url":null,"abstract":"Langerhans cell histiocytosis (LCH), previously known as histiocytosis X, is an idiopathic uncommon haematological condition affecting infants and young children but can occur at any age group characterized by clonal proliferation of abnormal Langerhans cells. Langerhans cells express an immunophenotype positive for S100 protein, CD1a and Langerin (CD207). Here we present a case of 2-year-old male patient presented with a multiple raw area associated with oozing, bleeding and crusted lesions were present over scalp, trunk and post-auricular areas. Radiographic examination revealed multiple osteolytic bone involvement. Histopathological examination revealed Langerhans cell histiocytosis. Immunophenotyping was positive for vimentin, CD1a, and S100. Based on radiological, histological and immunophenotyping findings suggestive of multisystem LCH. The purpose of this report is to describe a rare case of LCH in the 2-year-old male child with multisystem LCH involving skin, soft tissue and bones and to discuss clinical, radiological and histopathological features of LCH.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140689234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psoriasis is a common, chronic, inflammatory, and proliferative condition of the skin in which both genetic and environmental factors have a critical role. Various topical and systemic drugs which are given as rotational and sequential therapies are commonly prescribed as treatment. However, these are often not effective in prolonging the remission of chronic plaque psoriasis. To assess the therapeutic efficacy of cryotherapy in chronic plaque psoriasis. A prospective study on 50 patients with chronic plaque psoriasis was undertaken. Patients were treated with six consecutive sessions of cryotherapy at weekly intervals and further followed-up for another 6 weeks. It was observed that among 128 plaques of psoriasis vulgaris, 63 (49%) plaques showed G5 improvement while 40 (73%) among 55 plaques of palmoplantar psoriasis had G5 improvement. Thus, palmoplantar lesions responded better as compared with cutaneous lesions. Cryotherapy using nitrous oxide as cryogen has been proven to be an effective therapeutic modality not only for treatment but also for prolonging the remission in localized plaque psoriasis.
{"title":"Cryotherapy in chronic plaque psoriasis: an effective therapeutic modality","authors":"Rajiv Kumar, Mohita Mahajan, B. B. Mahajan","doi":"10.4103/ejdv.ejdv_38_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_38_23","url":null,"abstract":"\u0000 \u0000 Psoriasis is a common, chronic, inflammatory, and proliferative condition of the skin in which both genetic and environmental factors have a critical role. Various topical and systemic drugs which are given as rotational and sequential therapies are commonly prescribed as treatment. However, these are often not effective in prolonging the remission of chronic plaque psoriasis.\u0000 \u0000 \u0000 \u0000 To assess the therapeutic efficacy of cryotherapy in chronic plaque psoriasis.\u0000 \u0000 \u0000 \u0000 A prospective study on 50 patients with chronic plaque psoriasis was undertaken. Patients were treated with six consecutive sessions of cryotherapy at weekly intervals and further followed-up for another 6 weeks.\u0000 \u0000 \u0000 \u0000 It was observed that among 128 plaques of psoriasis vulgaris, 63 (49%) plaques showed G5 improvement while 40 (73%) among 55 plaques of palmoplantar psoriasis had G5 improvement. Thus, palmoplantar lesions responded better as compared with cutaneous lesions.\u0000 \u0000 \u0000 \u0000 Cryotherapy using nitrous oxide as cryogen has been proven to be an effective therapeutic modality not only for treatment but also for prolonging the remission in localized plaque psoriasis.\u0000","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140689607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Combination of topical silymarin 0.7%, dual toning and chemical peels (SeQuenCe protocol) for lichen planus pigmentosus in Indian skin","authors":"Rajat Kandhari","doi":"10.4103/ejdv.ejdv_30_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_30_23","url":null,"abstract":"","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140689387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shraddha Kote, Samruddhi Chopkar, B. Supekar, J. Mukhi
Anaplastic large-cell lymphoma (ALCL) is a non-Hodgkin T-cell lymphoma characterized by persistent expression of CD 30 antigen that represents 2–3% of non-Hodgkin lymphoma (NHL). ALCL may present as a primary cutaneous disease or systemic disease with secondary cutaneous involvement. World Health Organization (WHO) classifies ALCL into ALK-positive and ALK-negative ALCL. ALK-negative ALCL shows poor response on treatment and has a bad prognosis. We report locally aggressive and metastasizing primary cutaneous anaplastic lymphoma kinase-negative anaplastic large-cell lymphoma in a 58-year-old female, due to its paucity of literature.
{"title":"Anaplastic lymphoma kinase-negative anaplastic large-cell lymphoma","authors":"Shraddha Kote, Samruddhi Chopkar, B. Supekar, J. Mukhi","doi":"10.4103/ejdv.ejdv_17_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_17_23","url":null,"abstract":"Anaplastic large-cell lymphoma (ALCL) is a non-Hodgkin T-cell lymphoma characterized by persistent expression of CD 30 antigen that represents 2–3% of non-Hodgkin lymphoma (NHL). ALCL may present as a primary cutaneous disease or systemic disease with secondary cutaneous involvement. World Health Organization (WHO) classifies ALCL into ALK-positive and ALK-negative ALCL. ALK-negative ALCL shows poor response on treatment and has a bad prognosis. We report locally aggressive and metastasizing primary cutaneous anaplastic lymphoma kinase-negative anaplastic large-cell lymphoma in a 58-year-old female, due to its paucity of literature.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140690039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nevus sebaceous or comedo naevus is a rare benign hamartoma of the folliculo-sebaceous unit. It is characterized by bundles of papules having dilated follicular openings and keratinous plugs within. We report a case of nevus comedonicus diagnosed based on clinical-histopathological & dermoscopic findings in a 12-year-old male child treated who showed mild improvement with topical retinoids.
{"title":"Dermoscopy of Nevus Comdonicus","authors":"Shirin S. Gawali, B. Supekar, J. Mukhi","doi":"10.4103/ejdv.ejdv_20_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_20_23","url":null,"abstract":"Nevus sebaceous or comedo naevus is a rare benign hamartoma of the folliculo-sebaceous unit. It is characterized by bundles of papules having dilated follicular openings and keratinous plugs within. We report a case of nevus comedonicus diagnosed based on clinical-histopathological & dermoscopic findings in a 12-year-old male child treated who showed mild improvement with topical retinoids.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140689487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hazem L. Abdel-Aleem, Khaled M. Tawfik, Amaal A. Mofarreg, A. Y. Badran
Laser treatment signifies a safe option for managing Onychomycosis precisely in the presence of contraindication for antifungal drug use. Yellow Diode laser 577 nm has proved efficacy for managing different dermatological conditions as; vascular lesions, skin innovation and hair elimination. Nonetheless, it not yet been evaluated for treating Onychomycosis. We aimed to evaluate the efficacy of Yellow Diode laser 577 nm in treating Onychomycosis and to compare the result with the use of long-pulsed Neodymium-doped Yttrium Aluminum Garnet (Nd:Yag) 1064 nm laser. Thirty patients diagnosed clinically and mycologically as having Onychomycosis were recruited. The right side of the treated hand was subjected to treatment by Yellow Diode laser 577 nm, while the left side of the treated hand was subjected to treatment by of long-pulsed Nd:Yag 1064 nm laser. All patients received 6 sessions (1 month apart). The results were evaluated clinically using the Onychomycosis Severity Index (OSI), photographically and mycologically. Complete recovery in the side treated by Yellow Diode laser 577 nm was observed in 7 (23.3%) patients, while the side treated by long-pulsed Nd:Yag 1064 nm laser showed complete recovery in 4 patients (13.3%), with significant difference between both sides (p value=0.015*). Yellow Diode laser 577 nm is an effective safe and well-tolerated treatment option for managing Onychomycosis. It has proved better effectiveness than long-pulsed Nd;Yag 1064 nm laser in treating Onychomycosis.
{"title":"Yellow diode laser 577 nm versus neodymium-doped yttrium aluminum garnet laser (Nd:Yag) in treating onychomycosis: A comparative study","authors":"Hazem L. Abdel-Aleem, Khaled M. Tawfik, Amaal A. Mofarreg, A. Y. Badran","doi":"10.4103/ejdv.ejdv_52_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_52_23","url":null,"abstract":"\u0000 \u0000 Laser treatment signifies a safe option for managing Onychomycosis precisely in the presence of contraindication for antifungal drug use. Yellow Diode laser 577 nm has proved efficacy for managing different dermatological conditions as; vascular lesions, skin innovation and hair elimination. Nonetheless, it not yet been evaluated for treating Onychomycosis.\u0000 \u0000 \u0000 \u0000 We aimed to evaluate the efficacy of Yellow Diode laser 577 nm in treating Onychomycosis and to compare the result with the use of long-pulsed Neodymium-doped Yttrium Aluminum Garnet (Nd:Yag) 1064 nm laser.\u0000 \u0000 \u0000 \u0000 Thirty patients diagnosed clinically and mycologically as having Onychomycosis were recruited. The right side of the treated hand was subjected to treatment by Yellow Diode laser 577 nm, while the left side of the treated hand was subjected to treatment by of long-pulsed Nd:Yag 1064 nm laser. All patients received 6 sessions (1 month apart). The results were evaluated clinically using the Onychomycosis Severity Index (OSI), photographically and mycologically.\u0000 \u0000 \u0000 \u0000 Complete recovery in the side treated by Yellow Diode laser 577 nm was observed in 7 (23.3%) patients, while the side treated by long-pulsed Nd:Yag 1064 nm laser showed complete recovery in 4 patients (13.3%), with significant difference between both sides (p value=0.015*).\u0000 \u0000 \u0000 \u0000 Yellow Diode laser 577 nm is an effective safe and well-tolerated treatment option for managing Onychomycosis. It has proved better effectiveness than long-pulsed Nd;Yag 1064 nm laser in treating Onychomycosis.\u0000","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140686997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Hegazy, M. E. El Taieb, Abd A. M. Eliew, Ali Younis, Ahmed K. Ibrahim, Fatma E. A. Elfatah, H. Ibrahim
A biological indicator of cellular immunity is neopterin. In certain studies, psoriasis patients had higher serum, and urine neopterin levels, which were reduced following therapy. To evaluate the effect of acitretin versus narrowband ultraviolet B (NB-UVB) and combinations of them on psoriasis vulgaris and correlate it with neopterin level In this case-control research, a total of 120 respondents (30 healthy volunteers) served as the control group, in addition to 90 psoriasis patients randomly allocated into three equal groups: group (I): 30 patients received Acitretin for 3 months. Group (II): 30 patients were treated with NB-UVB. Group (III): 30 patients received Acitretin and NB-UVB (3 sessions/week) for 3 months. Serum neopterin levels were measured pre- and post-treatment. All patients were clinically and photographically evaluated using the Psoriasis Area and Severity Index (PASI) score. The study was registered at clinicaltrial.com. Approval numbers: NCT05401006 and date of registration: 1/6/2022. In this study, statistically significant higher serum neopterin levels have been found in psoriatic patients than healthy controls. We found a significant decrease in PASI scores in all groups. The relative reduction percentage in the PASI score was substantially different between groups (P<0.001). The highest decrease percentage in PASI score was reported in group III compared with group II (NB-UVB) and group I (Acitretin group), (P<0.001). The median s. neopterin levels after treatment varied substantially among the three groups (P<0.001). When compared with healthy controls, serum neopterin levels in psoriatic patients were substantially greater (P<0.05).
细胞免疫的一个生物指标是新蝶呤。在某些研究中，银屑病患者血清和尿液中的新蝶呤水平较高，但在治疗后有所降低。 评估阿曲汀与窄带紫外线 B（NB-UVB）及其组合对寻常型银屑病的影响，并将其与新蝶呤水平联系起来 在这项病例对照研究中，共有 120 名受访者（30 名健康志愿者）作为对照组，此外还有 90 名银屑病患者被随机分配到三个相同的组别：组（I）：30名患者接受阿曲汀治疗3个月。第二组30名患者接受NB-UVB治疗。第三组30 名患者接受阿曲汀和 NB-UVB 治疗（每周 3 次），为期 3 个月。测量治疗前后的血清蝶呤水平。使用银屑病面积和严重程度指数（PASI）对所有患者进行临床和照片评估。该研究已在 clinicaltrial.com 注册。批准号：NCT05401006 和注册日期：1/6/2022. 在这项研究中，我们发现银屑病患者的血清新蝶呤水平明显高于健康对照组。我们发现所有组别的 PASI 评分都有明显下降。各组间 PASI 评分的相对下降百分比差异很大（P<0.001）。与第二组（NB-UVB 组）和第一组（阿曲汀组）相比，第三组的 PASI 评分下降比例最高（P<0.001）。三组患者治疗后的中位蝶呤水平差异很大（P<0.001）。 与健康对照组相比，银屑病患者的血清蝶呤水平要高出很多（P<0.05）。
{"title":"Serum neopterin level in psoriatic patients treated with acitretin or narrowband ultraviolet B or both","authors":"E. Hegazy, M. E. El Taieb, Abd A. M. Eliew, Ali Younis, Ahmed K. Ibrahim, Fatma E. A. Elfatah, H. Ibrahim","doi":"10.4103/ejdv.ejdv_53_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_53_23","url":null,"abstract":"\u0000 \u0000 A biological indicator of cellular immunity is neopterin. In certain studies, psoriasis patients had higher serum, and urine neopterin levels, which were reduced following therapy.\u0000 \u0000 \u0000 \u0000 To evaluate the effect of acitretin versus narrowband ultraviolet B (NB-UVB) and combinations of them on psoriasis vulgaris and correlate it with neopterin level\u0000 \u0000 \u0000 \u0000 In this case-control research, a total of 120 respondents (30 healthy volunteers) served as the control group, in addition to 90 psoriasis patients randomly allocated into three equal groups: group (I): 30 patients received Acitretin for 3 months. Group (II): 30 patients were treated with NB-UVB. Group (III): 30 patients received Acitretin and NB-UVB (3 sessions/week) for 3 months. Serum neopterin levels were measured pre- and post-treatment. All patients were clinically and photographically evaluated using the Psoriasis Area and Severity Index (PASI) score. The study was registered at clinicaltrial.com. Approval numbers: NCT05401006 and date of registration: 1/6/2022.\u0000 \u0000 \u0000 \u0000 In this study, statistically significant higher serum neopterin levels have been found in psoriatic patients than healthy controls. We found a significant decrease in PASI scores in all groups. The relative reduction percentage in the PASI score was substantially different between groups (P<0.001). The highest decrease percentage in PASI score was reported in group III compared with group II (NB-UVB) and group I (Acitretin group), (P<0.001). The median s. neopterin levels after treatment varied substantially among the three groups (P<0.001).\u0000 \u0000 \u0000 \u0000 When compared with healthy controls, serum neopterin levels in psoriatic patients were substantially greater (P<0.05).\u0000","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140686869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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