S. Alashry, Manar Sallam, Manar Hassan, Eman Saber
Background Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit and is among the most common dermatological conditions worldwide. Adipokines are bioactive molecules secreted by adipocytes. Adiponectin is the most abundant adipokine. It has multiple properties, which includes sensitization of insulin, anti-inflammatory, and antiatherogenic effect. Objectives This study aims to evaluate serum adiponectin and lipid profile levels in patients with acne vulgaris and their correlation with each other and disease severity. Patients and methods This is a case-control study, conducted on a total of 90 patients with acne vulgaris and matched age, sex, and body mass index 70 healthy controls. Serum adiponectin and lipid profile levels were evaluated in all subjects. Results Total cholesterol (TC), total triglycrides (TG) and low density lipoprotein (LDL) were significantly higher in acne vulgaris cases, while high density lipoprotein (HDL) was statistically significant lower in cases compared to controls. Adiponectin concentration was significantly higher in acne vulgaris cases when compared to control group with positive correlations with female gender, disease severity, TC, LDL and significant negative correlation with HDL. Conclusions Adiponectin may play a role in the pathogenesis of acne vulgaris and may affect its severity. Evaluation of all acne patients for lipid profile and advice for healthy diets as an adjuvant method to acne treatment.
{"title":"Evaluation of serum adiponectin and lipid profile in patients with acne vulgaris","authors":"S. Alashry, Manar Sallam, Manar Hassan, Eman Saber","doi":"10.4103/ejdv.ejdv_6_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_6_23","url":null,"abstract":"Background Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit and is among the most common dermatological conditions worldwide. Adipokines are bioactive molecules secreted by adipocytes. Adiponectin is the most abundant adipokine. It has multiple properties, which includes sensitization of insulin, anti-inflammatory, and antiatherogenic effect. Objectives This study aims to evaluate serum adiponectin and lipid profile levels in patients with acne vulgaris and their correlation with each other and disease severity. Patients and methods This is a case-control study, conducted on a total of 90 patients with acne vulgaris and matched age, sex, and body mass index 70 healthy controls. Serum adiponectin and lipid profile levels were evaluated in all subjects. Results Total cholesterol (TC), total triglycrides (TG) and low density lipoprotein (LDL) were significantly higher in acne vulgaris cases, while high density lipoprotein (HDL) was statistically significant lower in cases compared to controls. Adiponectin concentration was significantly higher in acne vulgaris cases when compared to control group with positive correlations with female gender, disease severity, TC, LDL and significant negative correlation with HDL. Conclusions Adiponectin may play a role in the pathogenesis of acne vulgaris and may affect its severity. Evaluation of all acne patients for lipid profile and advice for healthy diets as an adjuvant method to acne treatment.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"43 1","pages":"208 - 211"},"PeriodicalIF":0.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48750394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noha Z Tawfik, Hoda Abdallah, Mona Abdullah, Hagar Alshaarawy, M. Atwa
Background The exact etiology of psoriasis remains unknown; nevertheless, it has been found that oxidative stress plays a vital role. Among the multiple antioxidant enzymes, genetic polymorphisms in the Glutathione S-Transferases (GSTs) led to an imbalance in the antioxidant system, resulting in increased levels of reactive oxygen species. Accordingly, the polymorphism in these genes could increase the susceptibility to psoriasis. Objectives To assess the association between Glutathione S-Transferase M1 (GSTM1) and Glutathione S Transferase Theta-1 (GSTT1) gene polymorphisms in psoriasis patients compared to healthy controls. Methods A total of 200 participants, 100 psoriasis cases who were assessed by the Psoriasis Area and Severity Index (PASI), and 100 healthy controls were included. DNA extraction was done followed by multiplex PCR to detect genetic polymorphism in the GSTM1 and GSTT1 genes, Finally, the relation between the presence of polymorphism and the severity of psoriasis was estimated. Results The null genotype frequency of GSTM1 and GSTT1 was 76.0% and 58.0%, respectively among psoriasis patients, while it was 58.0% and 55.0%, respectively among healthy controls. There was a significantly higher risk for psoriasis in patients with the null genotype GSTM1 (OR=2.293) as compared to controls. On the other hand, there was no statistically significant relation between their polymorphisms and family history, psoriasis severity, and PASI score. Conclusion The null genotype GSTM1 could increase the risk of psoriasis susceptibility especially among males.
{"title":"Glutathione S-transferase M1 and T1 gene polymorphisms in psoriasis patients: a pilot case-control study","authors":"Noha Z Tawfik, Hoda Abdallah, Mona Abdullah, Hagar Alshaarawy, M. Atwa","doi":"10.4103/ejdv.ejdv_5_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_5_23","url":null,"abstract":"Background The exact etiology of psoriasis remains unknown; nevertheless, it has been found that oxidative stress plays a vital role. Among the multiple antioxidant enzymes, genetic polymorphisms in the Glutathione S-Transferases (GSTs) led to an imbalance in the antioxidant system, resulting in increased levels of reactive oxygen species. Accordingly, the polymorphism in these genes could increase the susceptibility to psoriasis. Objectives To assess the association between Glutathione S-Transferase M1 (GSTM1) and Glutathione S Transferase Theta-1 (GSTT1) gene polymorphisms in psoriasis patients compared to healthy controls. Methods A total of 200 participants, 100 psoriasis cases who were assessed by the Psoriasis Area and Severity Index (PASI), and 100 healthy controls were included. DNA extraction was done followed by multiplex PCR to detect genetic polymorphism in the GSTM1 and GSTT1 genes, Finally, the relation between the presence of polymorphism and the severity of psoriasis was estimated. Results The null genotype frequency of GSTM1 and GSTT1 was 76.0% and 58.0%, respectively among psoriasis patients, while it was 58.0% and 55.0%, respectively among healthy controls. There was a significantly higher risk for psoriasis in patients with the null genotype GSTM1 (OR=2.293) as compared to controls. On the other hand, there was no statistically significant relation between their polymorphisms and family history, psoriasis severity, and PASI score. Conclusion The null genotype GSTM1 could increase the risk of psoriasis susceptibility especially among males.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"43 1","pages":"200 - 207"},"PeriodicalIF":0.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42910348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hassan Ibrahim, Nesreen Mostafa, A. Mawas, Atef Khalil, Eisa Hegazy
Background Nowadays, there are many benefits and adverse effects of tramadol. Aim This study evaluates the effects of royal jelly (RJ) on tramadol-induced testicular toxicity, sperm changes, oxidative stress, and histopathological changes in male albino rats. Methods Forty male albino rats in the experimental randomized study design were classified into four groups and were treated for 4 weeks. Control group, tramadol-treated group, tramadol plus RJ-treated group, and RJ-treated group. Assessment of reproductive hormones, antioxidants, semen analysis, and histopathological examinations of all groups was done. Results Administration of RJ with tramadol in male albino rats ameliorates testicular toxicity, sperm abnormalities, and oxidative stress, and improves histopathological changes induced by tramadol administration. Conclusions RJ may counteract the toxic testicular effect of tramadol in male albino rats, so we can use it widely in reproductive health and male infertility.
{"title":"Royal jelly improved tramadol-induced testicular dysfunction in male albino rats","authors":"Hassan Ibrahim, Nesreen Mostafa, A. Mawas, Atef Khalil, Eisa Hegazy","doi":"10.4103/ejdv.ejdv_47_22","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_47_22","url":null,"abstract":"Background Nowadays, there are many benefits and adverse effects of tramadol. Aim This study evaluates the effects of royal jelly (RJ) on tramadol-induced testicular toxicity, sperm changes, oxidative stress, and histopathological changes in male albino rats. Methods Forty male albino rats in the experimental randomized study design were classified into four groups and were treated for 4 weeks. Control group, tramadol-treated group, tramadol plus RJ-treated group, and RJ-treated group. Assessment of reproductive hormones, antioxidants, semen analysis, and histopathological examinations of all groups was done. Results Administration of RJ with tramadol in male albino rats ameliorates testicular toxicity, sperm abnormalities, and oxidative stress, and improves histopathological changes induced by tramadol administration. Conclusions RJ may counteract the toxic testicular effect of tramadol in male albino rats, so we can use it widely in reproductive health and male infertility.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"43 1","pages":"171 - 177"},"PeriodicalIF":0.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45681516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Syringocystadenoma papilliferum is benign hamartomatous adnexal tumor commonly occurring in childhood. Our patient was a 58-year-old lady presenting with an asymptomatic plaque on the scalp for past 6 years and postmenopausal bleeding for 8 months. Histopathological examination of scalp lesion confirmed the diagnosis of syringocystadenoma papilliferum which is known to be associated with mutations of genes like KRAS, PTCH. The patient also underwent surgical removal of uterine leiomyoma which is also associated with KRAS mutation.
{"title":"Syringocystadenoma papilliferum and leiomyoma of uterus","authors":"Bushra Muna","doi":"10.4103/ejdv.ejdv_3_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_3_23","url":null,"abstract":"Syringocystadenoma papilliferum is benign hamartomatous adnexal tumor commonly occurring in childhood. Our patient was a 58-year-old lady presenting with an asymptomatic plaque on the scalp for past 6 years and postmenopausal bleeding for 8 months. Histopathological examination of scalp lesion confirmed the diagnosis of syringocystadenoma papilliferum which is known to be associated with mutations of genes like KRAS, PTCH. The patient also underwent surgical removal of uterine leiomyoma which is also associated with KRAS mutation.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"43 1","pages":"222 - 224"},"PeriodicalIF":0.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42686569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Histoid leprosy is a rare variant of leprosy with distinctive immunological, clinical, microbiological, and histological characteristics first described by Wade in the year 1963. This is usually reported following dapsone monotherapy, irregular or improper therapy, and rarely de novo. Early diagnosis and treatment of histoid is important as it might serve as a reservoir and source of community spread of leprosy. In this article, we highlight the important aspects of clinical manifestations, immunological, histological, bacteriological, and management aspects of histoid leprosy.
{"title":"Histoid leprosy, an unusual variant of leprosy - review of literature","authors":"Soundarya Santhanakrishnaan, Manjumeena Dakshinamoorthy","doi":"10.4103/ejdv.ejdv_19_22","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_19_22","url":null,"abstract":"Histoid leprosy is a rare variant of leprosy with distinctive immunological, clinical, microbiological, and histological characteristics first described by Wade in the year 1963. This is usually reported following dapsone monotherapy, irregular or improper therapy, and rarely de novo. Early diagnosis and treatment of histoid is important as it might serve as a reservoir and source of community spread of leprosy. In this article, we highlight the important aspects of clinical manifestations, immunological, histological, bacteriological, and management aspects of histoid leprosy.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"43 1","pages":"161 - 163"},"PeriodicalIF":0.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47910310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Aboeldahab, SarahEl-Sayed Mohammed, M. El-Hamd, Ramadan Saleh
Background Vitiligo during childhood is common. Pediatric vitiligo has a profound effect on the quality of life of both children and their parents. Aims and objectives To investigate the epidemiologic characteristics of vitiligo among Egyptian children. Patients and methods A cross-sectional study was conducted and included children of both sexes from birth to less than 18 years of age. The study included schools and maternity and childhood care centers in Sohag Governorate, Upper Egypt, during the period from March 2019 to February 2020. Complete demographic and clinical information of children with vitiligo were recorded. Dermatological examination of patients with vitiligo was done. Vitiligo area and severity index of patients was calculated. Results Of 2594 screened children, 18 (0.7%) had vitiligo. The median age of children with vitiligo was 12 (2–17) years. The age interval from 13 to less than 18 years accounted for 44.4% of vitiligo cases. Females cases of vitiligo were more prevalent (61.1%). Overall, 72.2% of patients with vitiligo were resident of rural areas. Of the 18 cases with childhood vitiligo, 83.3% of cases had a history of consanguineous marriage and 66.5% had vitiligo vulgaris. A proportion of cases related the exacerbation of the disease to exposure to psychological stress. Conclusions Childhood vitiligo was detected in 0.7% of pediatric population in Upper Egypt. The majority of cases with childhood vitiligo had a history a consanguineous marriage between the parents. Psychic trauma was identified as a potential exacerbating factor of childhood vitiligo.
{"title":"Study of the epidemiologic characteristics of childhood vitiligo in Egyptian children","authors":"S. Aboeldahab, SarahEl-Sayed Mohammed, M. El-Hamd, Ramadan Saleh","doi":"10.4103/ejdv.ejdv_1_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_1_23","url":null,"abstract":"Background Vitiligo during childhood is common. Pediatric vitiligo has a profound effect on the quality of life of both children and their parents. Aims and objectives To investigate the epidemiologic characteristics of vitiligo among Egyptian children. Patients and methods A cross-sectional study was conducted and included children of both sexes from birth to less than 18 years of age. The study included schools and maternity and childhood care centers in Sohag Governorate, Upper Egypt, during the period from March 2019 to February 2020. Complete demographic and clinical information of children with vitiligo were recorded. Dermatological examination of patients with vitiligo was done. Vitiligo area and severity index of patients was calculated. Results Of 2594 screened children, 18 (0.7%) had vitiligo. The median age of children with vitiligo was 12 (2–17) years. The age interval from 13 to less than 18 years accounted for 44.4% of vitiligo cases. Females cases of vitiligo were more prevalent (61.1%). Overall, 72.2% of patients with vitiligo were resident of rural areas. Of the 18 cases with childhood vitiligo, 83.3% of cases had a history of consanguineous marriage and 66.5% had vitiligo vulgaris. A proportion of cases related the exacerbation of the disease to exposure to psychological stress. Conclusions Childhood vitiligo was detected in 0.7% of pediatric population in Upper Egypt. The majority of cases with childhood vitiligo had a history a consanguineous marriage between the parents. Psychic trauma was identified as a potential exacerbating factor of childhood vitiligo.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"43 1","pages":"186 - 190"},"PeriodicalIF":0.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44762858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sodium hypochlorite (0.1%) is a cost-effective and safe solution for trichomycosis (trichobacteriosis) axillaris: a novel use of an old solution","authors":"Muhammed Mukhtar","doi":"10.4103/ejdv.ejdv_36_22","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_36_22","url":null,"abstract":"","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"43 1","pages":"227 - 228"},"PeriodicalIF":0.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47637474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hemostatic comedone extraction using a customized micropipette tip and topical hypertonic saline","authors":"Muhammed Mukhtar","doi":"10.4103/ejdv.ejdv_35_22","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_35_22","url":null,"abstract":"","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"43 1","pages":"225 - 226"},"PeriodicalIF":0.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46625121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Thymic stromal lymphopoietin (TSLP), a proallergic cytokine, and T cell-derived CD40 ligand (CD40L) may collaborate to increase the production of IL-23 in psoriasis patients. One key cytokine, IL-23, is responsible for the unwarranted immune response in psoriasis sufferers. Aim The current study aims to shed light on the possible role of TSLP as a novel biomarker related to presence of psoriasis vulgaris lesions and its severe forms with exclusion of people with atopic dermatitis, allergic rhinitis, rheumatoid arthritis, graft versus host disease (GVHD), blood diseases and patient on anticoagulant therapy as well as pregnant and lactating females. Patients and methods 40 subjects with psoriasis vulgaris participated in the current case-controlled research, whereas 40 healthy volunteers of similar age and gender served as the control group. The degree and extent of the illness were evaluated utilizing the psoriasis area and severity index (PASI) score. Serum was separated after blood samples from the venous blood of the subjects and control participants were taken. As soon as possible, the serum samples were frozen at −20°C. The Sandwich Enzyme-Linked Immunosorbant Assay (ELISA) was utilized to quantify serum TSLP. Results The case group’s serum TSLP levels rose statistically substantially more than those of the control group. In the cases group, there was a statistically strong positive relation between serum TSLP levels and PASI scores (P: < 0.001). There is a statistically strong positive relation between serum TSLP and patients’ age and illness duration, a statistically substantial rise in blood TSLP values in psoriatic arthritis patients and smokers. Conclusion Patients with psoriasis have higher serum TSLP levels, which are proportional to the disease’s severity.
{"title":"Thymic stromal lymphopoietin: evaluating its role as a new marker related to presence of psoriasis vulgaris and its severity","authors":"H. Khaled, Y. Elghobashy, Enas M. El Sayed","doi":"10.4103/ejdv.ejdv_7_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_7_23","url":null,"abstract":"Background Thymic stromal lymphopoietin (TSLP), a proallergic cytokine, and T cell-derived CD40 ligand (CD40L) may collaborate to increase the production of IL-23 in psoriasis patients. One key cytokine, IL-23, is responsible for the unwarranted immune response in psoriasis sufferers. Aim The current study aims to shed light on the possible role of TSLP as a novel biomarker related to presence of psoriasis vulgaris lesions and its severe forms with exclusion of people with atopic dermatitis, allergic rhinitis, rheumatoid arthritis, graft versus host disease (GVHD), blood diseases and patient on anticoagulant therapy as well as pregnant and lactating females. Patients and methods 40 subjects with psoriasis vulgaris participated in the current case-controlled research, whereas 40 healthy volunteers of similar age and gender served as the control group. The degree and extent of the illness were evaluated utilizing the psoriasis area and severity index (PASI) score. Serum was separated after blood samples from the venous blood of the subjects and control participants were taken. As soon as possible, the serum samples were frozen at −20°C. The Sandwich Enzyme-Linked Immunosorbant Assay (ELISA) was utilized to quantify serum TSLP. Results The case group’s serum TSLP levels rose statistically substantially more than those of the control group. In the cases group, there was a statistically strong positive relation between serum TSLP levels and PASI scores (P: < 0.001). There is a statistically strong positive relation between serum TSLP and patients’ age and illness duration, a statistically substantial rise in blood TSLP values in psoriatic arthritis patients and smokers. Conclusion Patients with psoriasis have higher serum TSLP levels, which are proportional to the disease’s severity.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"43 1","pages":"212 - 219"},"PeriodicalIF":0.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45158007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Systemic lupus erythematosus (SLE) is an auto-immune disease affecting multiple organs. Among the cutaneous features, digital gangrene is considered to be very rare, occurring in only 1.3% of SLE patients. It is considered to be due to compromised perfusion of digits secondary to vasculitis, vasospasm and thomboembolism. This is the case report of a 35-year-old female who presented with acute blackish discoloration of toes of both feet associated with pain. She had no other features of SLE. But serology came out positive for SLE. The patient responded well to steroids, hydroxychloroquine, antiplatelet and anticoagulant medications and is currently under follow-up. This case report basically shows us that SLE should be considered as a possible differential diagnosis whenever there is a young patient presenting with digital gangrene without any other medical history.
{"title":"Systemic lupus erythematosus masquerading as gangrene - an infrequent presentation","authors":"Aditi Singh","doi":"10.4103/ejdv.ejdv_42_22","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_42_22","url":null,"abstract":"Systemic lupus erythematosus (SLE) is an auto-immune disease affecting multiple organs. Among the cutaneous features, digital gangrene is considered to be very rare, occurring in only 1.3% of SLE patients. It is considered to be due to compromised perfusion of digits secondary to vasculitis, vasospasm and thomboembolism. This is the case report of a 35-year-old female who presented with acute blackish discoloration of toes of both feet associated with pain. She had no other features of SLE. But serology came out positive for SLE. The patient responded well to steroids, hydroxychloroquine, antiplatelet and anticoagulant medications and is currently under follow-up. This case report basically shows us that SLE should be considered as a possible differential diagnosis whenever there is a young patient presenting with digital gangrene without any other medical history.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"43 1","pages":"220 - 221"},"PeriodicalIF":0.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42256639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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