新型贝克酵母介导的微波诱导还原外消旋3-酮-2-氮杂环丁酮：促进光学活性羟基β-内酰胺衍生物的进入

IF 0.9 Q4 CHEMISTRY, PHYSICAL Current Organocatalysis Pub Date : 2022-01-26 DOI:10.2174/2213337209666220126123630

Aparna Das, R. N. Yadav, B. Banik

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引用次数: 0

摘要

微波技术与酶催化相结合是一种自然友好的化学合成方法，溶剂损耗低，产物收率高。来自各种微生物的酶在微波辐射的辅助下可用于多种化合物的生物化学过程。本工作中，贝克酵母在有机溶剂中对α-酮-β-内酰胺进行了微波诱导反应，首次获得了具有光学活性的顺式和反式-α-羟基-β-内酰胺。这些羟基化合物是许多具有药用意义的天然产物的前体。

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A Novel Baker’s Yeast-Mediated Microwave-Induced Reduction of Racemic 3-Keto-2-Azetidinones: Facile Entry to Optically Active Hydroxy β-Lactam Derivatives

Microwave technology, together with enzymatic catalysis is a nature-friendly chemical synthesis method with low wastage of solvent and good yield of the products. Enzymes from various microorganisms can be used in the biochemical processes of a wide range of compounds assisted by microwave irradiation In this work, the microwave-induced reaction of α-keto β-lactams by Baker's yeast in organic solvent was conducted to afford optically active cis and trans-α-hydroxy-β-lactams for the first time. These hydroxy compounds are the precursors of numerous natural products of medicinal significances.

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Current Organocatalysis CHEMISTRY, PHYSICAL-

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2.00

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0.00%

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期刊介绍： Current Organocatalysis is an international peer-reviewed journal that publishes significant research in all areas of organocatalysis. The journal covers organo homogeneous/heterogeneous catalysis, innovative mechanistic studies and kinetics of organocatalytic processes focusing on practical, theoretical and computational aspects. It also includes potential applications of organocatalysts in the fields of drug discovery, synthesis of novel molecules, synthetic method development, green chemistry and chemoenzymatic reactions. This journal also accepts papers on methods, reagents, and mechanism of a synthetic process and technology pertaining to chemistry. Moreover, this journal features full-length/mini review articles within organocatalysis and synthetic chemistry. It is the premier source of organocatalysis and synthetic methods related information for chemists, biologists and engineers pursuing research in industry and academia.