{"title":"成纤维细胞生长因子2。","authors":"","doi":"10.1016/j.diff.2023.10.001","DOIUrl":null,"url":null,"abstract":"<div><p><span>Fibroblast Growth Factor 2<span><span> (FGF2), also known as basic fibroblast growth factor, is a potent stimulator of growth and differentiation in multiple tissues. Its discovery traces back over 50 years ago when it was first isolated from bovine pituitary extracts due to its ability to stimulate fibroblast proliferation. Subsequent studies investigating the </span>genomic structure of </span></span><em>FGF2</em><span><span> identified multiple protein isoforms<span>, categorized as the low molecular weight and high molecular weight FGF2. These isoforms arise from alternative translation initiation events and exhibit unique molecular and cellular functions. In this concise review, we aim to provide an overview of what is currently known about the structure, expression, and functions of the FGF2 isoforms within the contexts of development, </span></span>homeostasis, and disease.</span></p></div>","PeriodicalId":50579,"journal":{"name":"Differentiation","volume":"139 ","pages":"Article 100733"},"PeriodicalIF":2.2000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Fibroblast growth factor 2\",\"authors\":\"\",\"doi\":\"10.1016/j.diff.2023.10.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Fibroblast Growth Factor 2<span><span> (FGF2), also known as basic fibroblast growth factor, is a potent stimulator of growth and differentiation in multiple tissues. Its discovery traces back over 50 years ago when it was first isolated from bovine pituitary extracts due to its ability to stimulate fibroblast proliferation. Subsequent studies investigating the </span>genomic structure of </span></span><em>FGF2</em><span><span> identified multiple protein isoforms<span>, categorized as the low molecular weight and high molecular weight FGF2. These isoforms arise from alternative translation initiation events and exhibit unique molecular and cellular functions. In this concise review, we aim to provide an overview of what is currently known about the structure, expression, and functions of the FGF2 isoforms within the contexts of development, </span></span>homeostasis, and disease.</span></p></div>\",\"PeriodicalId\":50579,\"journal\":{\"name\":\"Differentiation\",\"volume\":\"139 \",\"pages\":\"Article 100733\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Differentiation\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0301468123000725\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Differentiation","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0301468123000725","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Fibroblast Growth Factor 2 (FGF2), also known as basic fibroblast growth factor, is a potent stimulator of growth and differentiation in multiple tissues. Its discovery traces back over 50 years ago when it was first isolated from bovine pituitary extracts due to its ability to stimulate fibroblast proliferation. Subsequent studies investigating the genomic structure of FGF2 identified multiple protein isoforms, categorized as the low molecular weight and high molecular weight FGF2. These isoforms arise from alternative translation initiation events and exhibit unique molecular and cellular functions. In this concise review, we aim to provide an overview of what is currently known about the structure, expression, and functions of the FGF2 isoforms within the contexts of development, homeostasis, and disease.
期刊介绍：
Differentiation is a multidisciplinary journal dealing with topics relating to cell differentiation, development, cellular structure and function, and cancer. Differentiation of eukaryotes at the molecular level and the use of transgenic and targeted mutagenesis approaches to problems of differentiation are of particular interest to the journal.
The journal will publish full-length articles containing original work in any of these areas. We will also publish reviews and commentaries on topics of current interest.
The principal subject areas the journal covers are: • embryonic patterning and organogenesis
• human development and congenital malformation
• mechanisms of cell lineage commitment
• tissue homeostasis and oncogenic transformation
• establishment of cellular polarity
• stem cell differentiation
• cell reprogramming mechanisms
• stability of the differentiated state
• cell and tissue interactions in vivo and in vitro
• signal transduction pathways in development and differentiation
• carcinogenesis and cancer
• mechanisms involved in cell growth and division especially relating to cancer
• differentiation in regeneration and ageing
• therapeutic applications of differentiation processes.
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