膳食果糖介导的脂肪细胞代谢驱动抗肿瘤CD8+T细胞反应。

Cell metabolism Pub Date : 2023-12-05 Epub Date: 2023-10-19 DOI:10.1016/j.cmet.2023.09.011
Yuerong Zhang, Xiaoyan Yu, Rujuan Bao, Haiyan Huang, Chuanjia Gu, Qianming Lv, Qiaoqiao Han, Xian Du, Xu-Yun Zhao, Youqiong Ye, Ren Zhao, Jiayuan Sun, Qiang Zou
{"title":"膳食果糖介导的脂肪细胞代谢驱动抗肿瘤CD8+T细胞反应。","authors":"Yuerong Zhang, Xiaoyan Yu, Rujuan Bao, Haiyan Huang, Chuanjia Gu, Qianming Lv, Qiaoqiao Han, Xian Du, Xu-Yun Zhao, Youqiong Ye, Ren Zhao, Jiayuan Sun, Qiang Zou","doi":"10.1016/j.cmet.2023.09.011","DOIUrl":null,"url":null,"abstract":"<p><p>Fructose consumption is associated with tumor growth and metastasis in mice, yet its impact on antitumor immune responses remains unclear. Here, we show that dietary fructose modulates adipocyte metabolism to enhance antitumor CD8<sup>+</sup> T cell immune responses and control tumor growth. Transcriptional profiling of tumor-infiltrating CD8<sup>+</sup> T cells reveals that dietary fructose mediates attenuated transition of CD8<sup>+</sup> T cells to terminal exhaustion, leading to a superior antitumor efficacy. High-fructose feeding initiates adipocyte-derived leptin production in an mTORC1-dependent manner, thereby triggering leptin-boosted antitumor CD8<sup>+</sup> T cell responses. Importantly, high plasma leptin levels are correlated with elevated plasma fructose concentrations and improved antitumor CD8<sup>+</sup> T cell responses in patients with lung cancer. Our study characterizes a critical role for dietary fructose in shaping adipocyte metabolism to prime antitumor CD8<sup>+</sup> T cell responses and highlights that the fructose-leptin axis may be harnessed for cancer immunotherapy.</p>","PeriodicalId":93927,"journal":{"name":"Cell metabolism","volume":" ","pages":"2107-2118.e6"},"PeriodicalIF":0.0000,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dietary fructose-mediated adipocyte metabolism drives antitumor CD8<sup>+</sup> T cell responses.\",\"authors\":\"Yuerong Zhang, Xiaoyan Yu, Rujuan Bao, Haiyan Huang, Chuanjia Gu, Qianming Lv, Qiaoqiao Han, Xian Du, Xu-Yun Zhao, Youqiong Ye, Ren Zhao, Jiayuan Sun, Qiang Zou\",\"doi\":\"10.1016/j.cmet.2023.09.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Fructose consumption is associated with tumor growth and metastasis in mice, yet its impact on antitumor immune responses remains unclear. Here, we show that dietary fructose modulates adipocyte metabolism to enhance antitumor CD8<sup>+</sup> T cell immune responses and control tumor growth. Transcriptional profiling of tumor-infiltrating CD8<sup>+</sup> T cells reveals that dietary fructose mediates attenuated transition of CD8<sup>+</sup> T cells to terminal exhaustion, leading to a superior antitumor efficacy. High-fructose feeding initiates adipocyte-derived leptin production in an mTORC1-dependent manner, thereby triggering leptin-boosted antitumor CD8<sup>+</sup> T cell responses. Importantly, high plasma leptin levels are correlated with elevated plasma fructose concentrations and improved antitumor CD8<sup>+</sup> T cell responses in patients with lung cancer. Our study characterizes a critical role for dietary fructose in shaping adipocyte metabolism to prime antitumor CD8<sup>+</sup> T cell responses and highlights that the fructose-leptin axis may be harnessed for cancer immunotherapy.</p>\",\"PeriodicalId\":93927,\"journal\":{\"name\":\"Cell metabolism\",\"volume\":\" \",\"pages\":\"2107-2118.e6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell metabolism\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.cmet.2023.09.011\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/10/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell metabolism","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.cmet.2023.09.011","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/10/19 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

果糖的摄入与小鼠的肿瘤生长和转移有关,但其对抗肿瘤免疫反应的影响尚不清楚。在这里,我们发现膳食果糖调节脂肪细胞代谢,以增强抗肿瘤CD8+T细胞免疫反应并控制肿瘤生长。肿瘤浸润性CD8+T细胞的转录谱分析表明,膳食果糖介导CD8+T淋巴细胞向终末耗竭的减弱过渡,从而产生优异的抗肿瘤功效。高果糖喂养以mTORC1依赖的方式启动脂肪细胞衍生的瘦素的产生,从而触发瘦素增强的抗肿瘤CD8+T细胞反应。重要的是,高血浆瘦素水平与癌症患者血浆果糖浓度升高和抗肿瘤CD8+T细胞反应改善有关。我们的研究表明,膳食果糖在形成脂肪细胞代谢以引发抗肿瘤CD8+T细胞反应中的关键作用,并强调果糖-肽轴可用于癌症免疫疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses.

Fructose consumption is associated with tumor growth and metastasis in mice, yet its impact on antitumor immune responses remains unclear. Here, we show that dietary fructose modulates adipocyte metabolism to enhance antitumor CD8+ T cell immune responses and control tumor growth. Transcriptional profiling of tumor-infiltrating CD8+ T cells reveals that dietary fructose mediates attenuated transition of CD8+ T cells to terminal exhaustion, leading to a superior antitumor efficacy. High-fructose feeding initiates adipocyte-derived leptin production in an mTORC1-dependent manner, thereby triggering leptin-boosted antitumor CD8+ T cell responses. Importantly, high plasma leptin levels are correlated with elevated plasma fructose concentrations and improved antitumor CD8+ T cell responses in patients with lung cancer. Our study characterizes a critical role for dietary fructose in shaping adipocyte metabolism to prime antitumor CD8+ T cell responses and highlights that the fructose-leptin axis may be harnessed for cancer immunotherapy.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipolysis, and gluconeogenesis via CAMKII activation. Obesity intensifies sex-specific interferon signaling to selectively worsen central nervous system autoimmunity in females. Serine and glycine physiology reversibly modulate retinal and peripheral nerve function. TNF compromises intestinal bile-acid tolerance dictating colitis progression and limited infliximab response. Acetate enables metabolic fitness and cognitive performance during sleep disruption.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1