侵入性记忆错误与积极型精神分裂症有关。

IF 2.3 Q2 PSYCHIATRY Schizophrenia Research-Cognition Pub Date : 2023-10-12 DOI:10.1016/j.scog.2023.100291
William N. Koller , Tyrone D. Cannon
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引用次数: 0

摘要

精神分裂症的特点是记忆障碍,但其不同的症状群(即阳性、阴性、无组织)与记忆功能障碍的特定方面之间的关系仍不明确。在本研究中,我们汇编了一个大的模拟样本(N=795),以测试阳性症状与阴性和无组织症状是否与识别记忆过程中的虚警和失误有着独特和差异的关系。混合效应β回归分析显示,阳性精神分裂症和妄想症与假警报的相关性比与失误的相关性更强。无序分裂型表现出相似的模式,尽管程度较低;阴性分裂型与假警和失误均无显著关系。我们认为,那些阳性分裂型较高的人在识别记忆过程中特别容易将信号与噪声刺激错误归因——这是记忆损伤的“侵入性”特征,其中与上下文无关的刺激会触发虚假的检索事件——并推测可能导致这种不对称的神经过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Intrusive-like memory errors associate with positive schizotypy

Schizophrenia is characterized by memory impairments, yet the relationships between its distinct symptom clusters (i.e., positive, negative, disorganized) and specific aspects of memory dysfunction remain poorly characterized. In the present study, we compiled a large analog sample (N = 795) to test whether positive symptoms, versus negative and disorganized symptoms, were uniquely and differentially related to false alarm versus miss errors during recognition memory. Mixed-effects beta regression analyses revealed that both positive schizotypy and paranoia were more strongly associated with false alarms than misses. Disorganized schizotypy showed a similar pattern, though to a lesser extent; negative schizotypy showed a significant relationship with neither false alarm nor miss errors. We suggest that those higher in positive schizotypy are especially prone to misattribute signal to noise stimuli during recognition memory – characteristic of an “intrusive-like” profile of memory impairment, wherein context-irrelevant stimuli trigger spurious retrieval events – and speculate on the neural processes that might give rise to this asymmetry.

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来源期刊
CiteScore
5.60
自引率
10.70%
发文量
54
审稿时长
67 days
期刊最新文献
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