大麻二酚(CBD)在神经系统疾病中新出现的治疗潜力:综合综述。

IF 2.7 4区 医学 Q2 CLINICAL NEUROLOGY Behavioural Neurology Pub Date : 2023-10-12 eCollection Date: 2023-01-01 DOI:10.1155/2023/8825358
Kuldeep Singh, Bharat Bhushan, Dilip Kumar Chanchal, Satish Kumar Sharma, Ketki Rani, Manoj Kumar Yadav, Prateek Porwal, Shivendra Kumar, Ashwani Sharma, Tarun Virmani, Girish Kumar, Abdullah Al Noman
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引用次数: 0

摘要

大麻二酚(CBD)来源于大麻,因其潜在的治疗应用而备受关注。这项彻底的分析探讨了CBD在治疗包括癫痫、多发性硬化症、帕金森病和阿尔茨海默病在内的神经疾病方面日益重要的意义,这些疾病在全球范围内引起了重大的医疗保健问题。尽管缺乏可用的治疗方法,但CBD在临床前和临床研究中已被证明具有多种药理作用,使其成为一个有趣的竞争对手。这篇综述汇集了关于内源性大麻素和神经递质系统以及抗炎途径的最新发现,这些都是CBD作用模式的基础。包括对一系列神经系统疾病的综合疗效和安全性评估,包括人体试验、体外研究和动物模型。该研究包括CBD如何保护神经元、控制神经炎症、抵御氧化应激和管理神经元兴奋性。这项研究强调了CBD研究中现有的临床研究和未来的可能性,解决了调节并发症和矛盾结果等研究问题,并主张进一步研究治疗效果和理想剂量方法。通过强调CBD改善患者幸福感的潜力,本研究对其作为神经疾病治疗干预措施的适用性提出了一个修正的观点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Emerging Therapeutic Potential of Cannabidiol (CBD) in Neurological Disorders: A Comprehensive Review.

Cannabidiol (CBD), derived from Cannabis sativa, has gained remarkable attention for its potential therapeutic applications. This thorough analysis explores the increasing significance of CBD in treating neurological conditions including epilepsy, multiple sclerosis, Parkinson's disease, and Alzheimer's disease, which present major healthcare concerns on a worldwide scale. Despite the lack of available therapies, CBD has been shown to possess a variety of pharmacological effects in preclinical and clinical studies, making it an intriguing competitor. This review brings together the most recent findings on the endocannabinoid and neurotransmitter systems, as well as anti-inflammatory pathways, that underlie CBD's modes of action. Synthesized efficacy and safety assessments for a range of neurological illnesses are included, covering human trials, in vitro studies, and animal models. The investigation includes how CBD could protect neurons, control neuroinflammation, fend off oxidative stress, and manage neuronal excitability. This study emphasizes existing clinical studies and future possibilities in CBD research, addressing research issues such as regulatory complications and contradicting results, and advocates for further investigation of therapeutic efficacy and ideal dose methodologies. By emphasizing CBD's potential to improve patient well-being, this investigation presents a revised viewpoint on its suitability as a therapeutic intervention for neurological illnesses.

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来源期刊
Behavioural Neurology
Behavioural Neurology 医学-临床神经学
CiteScore
5.40
自引率
3.60%
发文量
52
审稿时长
>12 weeks
期刊介绍: Behavioural Neurology is a peer-reviewed, Open Access journal which publishes original research articles, review articles and clinical studies based on various diseases and syndromes in behavioural neurology. The aim of the journal is to provide a platform for researchers and clinicians working in various fields of neurology including cognitive neuroscience, neuropsychology and neuropsychiatry. Topics of interest include: ADHD Aphasia Autism Alzheimer’s Disease Behavioural Disorders Dementia Epilepsy Multiple Sclerosis Parkinson’s Disease Psychosis Stroke Traumatic brain injury.
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