Recent advances in stimuli-response mechanisms of nano-enabled controlled-release fertilizers and pesticides

Nanotechnology-enabled fertilizers and pesticides, especially those capable of releasing plant nutrients or pesticide active ingredients (AIs) in a controlled manner, can effectively enhance crop nutrition and protection while minimizing the environmental impacts of agricultural activities. Herein, we review the fundamentals and recent advances in nanofertilizers and nanopesticides with controlled-release properties, enabled by nanocarriers responsive to environmental and biological stimuli, including pH change, temperature, light, redox conditions, and the presence of enzymes. For pH-responsive nanocarriers, pH change can induce structural changes or degradation of the nanocarriers or cleave the bonding between nutrients/pesticide AIs and the nanocarriers. Similarly, temperature response typically involves structural changes in nanocarriers, and higher temperatures can accelerate the release by diffusion promoting or bond breaking. Photothermal materials enable responses to infrared light, and photolabile moieties (e.g., o-nitrobenzyl and azobenzene) are required for achieving ultraviolet light responses. Redox-responsive nanocarriers contain disulfide bonds or ferric iron, whereas enzyme-responsive nanocarriers typically contain the enzyme’s substrate as a building block. For fabricating nanofertilizers, pH-responsive nanocarriers have been well explored, but only a few studies have reported temperature- and enzyme-responsive nanocarriers. In comparison, there have been more reports on nanopesticides, which are responsive to a range of stimuli, including many with dual- or triple-responsiveness. Nano-enabled controlled-release fertilizers and pesticides show tremendous potential for enhancing the utilization efficiency of nutrients and pesticide AIs. However, to expand their practical applications, future research should focus on optimizing their performance under realistic conditions, lowering costs, and addressing regulatory and public concerns over environmental and safety risks.