血清BDNF预测长达一个月的居住冥想静修期间端粒长度的增加

Quinn A. Conklin , Cavan E. Patterson , Brandon G. King , Anthony P. Zanesco , Jennifer J. Pokorny , María Jesús Álvarez-López , Marta Cosín-Tomás , Perla Kaliman , Clifford D. Saron
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摘要

脑源性神经营养因子(BDNF)是一种与学习、记忆和神经可塑性有关的调节性神经蛋白。研究发现,冥想干预参与者的外周BDNF增加,这表明BDNF可能在冥想训练中的学习和习惯形成中发挥作用。在这项研究中,我们评估了在为期一个月的冥想静修中外周BDNF蛋白和基因表达的变化。我们还探讨了BDNF与先前报道的端粒酶活性和端粒长度(与细胞衰老和寿命有关的生物标志物)之间的关系。方法所有参与者都是有经验的冥想者。静修组参与者(n=28)在静修开始时和静修3周后接受评估。对照组参与者(n=34)年龄、性别和冥想经历相似,也在3周的时间间隔内进行了评估。测定血清BDNF。在PBMC中测量BDNF转录物、端粒长度和端粒酶活性。结果在撤退参与者中,撤退开始时血清BDNF水平较高预示着撤退过程中端粒长度的增加。我们还发现血清BDNF与端粒酶活性呈负相关。与我们的预测相反,我们没有观察到血清BDNF或BDNF转录物的平均水平变化作为消退的函数。结论我们的研究结果表明,基础BDNF水平可能在端粒生物学中观察到的撤退相关改善中发挥作用。
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Serum BDNF predicts increases in telomere length during a month-long residential meditation retreat

Background

Brain-derived neurotrophic factor (BDNF) is a modulatory neuroprotein implicated in learning, memory, and neuroplasticity. Studies have found increased peripheral BDNF in participants of meditation interventions, indicating that BDNF may play a role in the learning and habit formation that occurs with meditation training. In this study, we assessed changes in peripheral BDNF protein and gene expression across a month-long insight meditation retreat. We also explored relationships between BDNF and previously reported measures of telomerase activity and telomere length—biomarkers implicated in cell aging and longevity.

Method

All participants were experienced meditators. Retreat group participants (n = 28) were assessed at the beginning of, and 3 weeks into, a silent residential retreat. Control group participants (n = 34), who were similar in age, gender, and meditation experience, were also assessed across a 3-week interval. BDNF was measured in serum. BDNF transcripts, telomere length, and telomerase activity were measured in PBMCs.

Results

In retreat participants, higher levels of serum BDNF at the beginning of retreat predicted increases in telomere length during retreat. We also found negative correlations between serum BDNF and telomerase activity. Contrary to our prediction, we observed no mean-level change in serum BDNF or BDNF transcripts as a function of retreat.

Conclusion

Our results suggest that basal BDNF levels may play a role in retreat-related improvements observed in telomere biology.

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