重组促红细胞生成素治疗可提高糖尿病肾病患者血清足细胞标志物水平

Lingfeng Zeng , Jack Kit-Chung Ng , Winston Wing-Shing Fung , Gordon Chun-Kau Chan , Kai-Ming Chow , Cheuk-Chun Szeto
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引用次数: 0

摘要

背景重组人红细胞生成素(rHuEPO)是治疗肾性贫血的有效药物。最近,有证据表明rHuEPO可以减少糖尿病肾病(DKD)中足细胞的损伤。然而,尚未发表关于rHuEPO治疗DKD前后足细胞损伤标志物水平变化的研究。方法检测49例DKD患者在rHuEPO治疗前、治疗后12周和36周的血清nephrin和podocalyxin水平及其相应的血浆mRNA水平。结果rHuEPO治疗后,血清nephrin(p=0.002)和足角蛋白水平(p=0.09)以及相应的血浆mRNA水平(p<0.0001)均降低。血清nephrin和podocin水平的变化与伴随的血红蛋白水平的变化呈显著的负相关(r分别为-0.670和-0.739,两者均p<0.0001),但与肾功能或蛋白尿的变化无关。结论rHuEPO治疗后DKD患者血清nephrin和podocalyxin水平及相应的血浆信使核糖核酸水平显著降低,血清nephren和podcaly xin水平的变化与血红蛋白水平的变化相关。rHuEPO对足细胞损伤的作用值得进一步研究。
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Recombinant erythropoietin treatment improves serum podocyte marker levels in diabetic kidney disease
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来源期刊
Advances in biomarker sciences and technology
Advances in biomarker sciences and technology Biotechnology, Clinical Biochemistry, Molecular Medicine, Public Health and Health Policy
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审稿时长
20 weeks
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