循环微rna与易感和新诊断的2型糖尿病病例的关系

Syed Tasleem Raza , Saliha Rizvi , Sheeba Afreen , Sanchita Srivastava , Zainab Siddiqui , Naseem Fatima , Zeba Siddiqi , Farzana Mahdi
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引用次数: 1

摘要

背景糖尿病(DM)是一系列代谢性疾病,其原因是胰岛素分泌失调或其作用导致血糖水平异常高,与长期损伤、器官衰竭有关,尤其是眼睛、心脏、肾脏、血管和神经,其频率在全球范围内逐渐增加。目的本研究旨在评估新诊断的T2DM易感个体和健康对照个体的血浆miRNA-126、miRNA-486、miRNA-223和miRNA-375水平。方法在本研究中,我们使用实时聚合酶链式反应(RT-PCR)(Taqman®)评估了三个研究组(包括健康对照组(N=36)、新诊断的T2DM(N=29)和T2DM易感个体(N=30))血浆中与T2DM相关的miRNA-miRNA-126、miRNA-486、miRNA-223和miRNA-375。所有统计分析均采用SPSS 21版软件进行。结果发现这些参数之间存在显著相关性。与健康对照组相比,miR-126、miR-486、miR-223和miR-375的表达水平在T2DM患者中下调,在T2DM易感个体中进一步降低。此外,在组合组分析中,miR-223和miR-375与HbA1c水平呈负相关,而所有四种miR均与FBS水平呈负相关性。结论这些观察到的关联进一步表明,miR-126、miR-223和miR-375可能参与葡萄糖代谢和血糖控制的调节。它们的下调可能导致胰岛素信号受损、β细胞功能障碍、炎症和葡萄糖稳态紊乱,所有这些都是糖尿病的特征。
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Association of the circulating micro-RNAs with susceptible and newly diagnosed type 2 diabetes mellitus cases
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来源期刊
Advances in biomarker sciences and technology
Advances in biomarker sciences and technology Biotechnology, Clinical Biochemistry, Molecular Medicine, Public Health and Health Policy
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20 weeks
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