骨骼肌重塑和适应中的线粒体蛋白输入和UPRmt

IF 6.2 2区 生物学 Q1 CELL BIOLOGY Seminars in cell & developmental biology Pub Date : 2023-07-15 DOI:10.1016/j.semcdb.2022.01.002
Brandon J. Richards, Mikhaela Slavin, Ashley N. Oliveira, Victoria C. Sanfrancesco, David A. Hood
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引用次数: 3

摘要

线粒体的生物发生需要细胞核和线粒体基因组的协调表达。然而,细胞器内的绝大多数基因产物在细胞核中编码,在胞质溶胶中合成,并通过蛋白质输入机制输入线粒体,这允许蛋白质进入以扩大线粒体网络。蛋白质一旦进入体内,就会经历由包括未折叠蛋白质反应(UPRmt)的酶引起的成熟和折叠过程。蛋白质输入和UPRmt活性必须与mtDNA编码的亚基合成同步并匹配,以正确组装电子传输链复合物,避免蛋白毒性。这篇综述讨论了哺乳动物骨骼肌中导入和UPRmt系统的功能,以及运动如何以时间依赖的方式改变这些途径的平衡,导致线粒体含量的新稳定状态,从而增强氧化能力和改善肌肉健康。
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Mitochondrial protein import and UPRmt in skeletal muscle remodeling and adaptation

The biogenesis of mitochondria requires the coordinated expression of the nuclear and the mitochondrial genomes. However, the vast majority of gene products within the organelle are encoded in the nucleus, synthesized in the cytosol, and imported into mitochondria via the protein import machinery, which permit the entry of proteins to expand the mitochondrial network. Once inside, proteins undergo a maturation and folding process brought about by enzymes comprising the unfolded protein response (UPRmt). Protein import and UPRmt activity must be synchronized and matched with mtDNA-encoded subunit synthesis for proper assembly of electron transport chain complexes to avoid proteotoxicity. This review discusses the functions of the import and UPRmt systems in mammalian skeletal muscle, as well as how exercise alters the equilibrium of these pathways in a time-dependent manner, leading to a new steady state of mitochondrial content resulting in enhanced oxidative capacity and improved muscle health.

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来源期刊
CiteScore
15.10
自引率
1.40%
发文量
310
审稿时长
9.1 weeks
期刊介绍: Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.
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