一个不寻常的鞘内巴氯芬泵失败后植入13个月

Kevin E. Vorenkamp , Savan H. Gandhi , Andrew S. Manolides , Daniel T. Warren
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引用次数: 0

摘要

目的报告一例鞘内泵衰竭的病例,该病例在鞘内注射巴氯芬的益处减少数月后发生,并提高人们对鞘内泵功能障碍可能发生而不会引发事件的认识。病例报告一名患有多发性硬化症和痉挛性截瘫的40岁女性在鞘内注射巴氯芬治疗稳定10个月后出现痉挛恶化。在寻找其他原因后,发现这是由于植入后仅13个月的泵故障。经过对泵的询问和与制造商的讨论,紧急更换了泵,患者恢复了治疗效果,没有进一步的并发症。结论我们在本文中提出了我们认为是第一例经证实的泵故障导致植入后13个月内鞘内巴氯芬输送中断的报告。由于急性巴氯芬停药的严重性,诊断后紧急更换了泵。由于患者及其医疗服务提供者的警惕性,她没有出现任何不良事件。鼓励医疗保健提供者承认在类似情况下鞘内泵发生故障的可能性,在系统检查潜在问题的同时确保患者安全。
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An unusual intrathecal baclofen pump failure thirteen months after implantation

Objective

To report a case of intrathecal pump failure following months of diminishing benefit from intrathecal baclofen, and to heighten awareness that intrathecal pump malfunction can occur without precipitating events.

Case report

A 40 year-old woman with multiple sclerosis and spastic paraplegia developed worsening spasticity after ten months of therapeutic stability with intrathecal baclofen. After other causes were pursued, this was discovered to be due to pump malfunction only thirteen months after implantation. After pump interrogation and discussion with the manufacturer the pump was replaced urgently and the patient regained therapeutic benefit and had no further complications.

Conclusions

We present herein what we believe to be the first report of a verified pump malfunction resulting in disruption of intrathecal baclofen delivery within thirteen months of implantation. Due to the possible severity of acute baclofen withdrawal, the pump was replaced urgently after diagnosis. Because of the patient's and her healthcare providers' vigilance, she experienced no adverse events. Healthcare providers are encouraged to acknowledge the possibility of intrathecal pump malfunction in similar scenarios, ensuring patient safety while systematically examining the underlying problem.

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