修饰柑橘果胶对cdcl2处理的秀丽隐杆线虫的癌症相关通路具有预防作用

IF 4.6 Q1 CHEMISTRY, APPLIED Food Hydrocolloids for Health Pub Date : 2023-10-04 DOI:10.1016/j.fhfh.2023.100161
Denia Cai Shi , Arland T. Hotchkiss Jr , Michael A. Lawton , Rong Di
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引用次数: 0

摘要

氯化镉(CdCl2)是一种有毒化合物,因农业和工业来源而在环境中被发现为污染物。已知暴露于Cd2+会促进恶性肿瘤,如肺癌和白血病。虽然目前治疗镉毒性的药物侧重于促进身体排泄的治疗方法,但对镉暴露后改善健康的治疗方法研究较少。改性柑橘果胶(MCP)是一种从柑橘皮中提取的多糖,已被证明可诱导髓系白血病细胞的自然杀伤细胞活性,也可作为天然螯合剂帮助健康人体排出有毒金属。我们假设MCP可能通过癌症相关途径对抗CdCl2的毒性。本研究调查了MCP对秀丽隐杆线虫CdCl2毒性的影响,秀丽隐杆虫与哺乳动物有许多癌症相关途径。结果表明,MCP能够显著对抗CdCl2对秀丽隐杆线虫寿命和发育的毒性作用。我们的研究表明,MCP的有益作用可能是由于其能够减轻CdCl2对基因表达的影响,特别是在与细胞凋亡、肿瘤诱导和抑制以及炎症相关的保守途径中。
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Modified citrus pectin confers a preventative effect on cancer-related pathways in CdCl2-treated C. elegans

Cadmium chloride (CdCl2) is a toxic compound found as a pollutant in the environment due to agricultural and industrial sources. Exposure to Cd2+ is known to promote malignant tumors such as lung cancer and leukemia. While the current medications for cadmium toxicity focus on treatments to promote the excretion from the body, treatments to improve health after cadmium exposure are less well studied. Modified citrus pectin (MCP) is a polysaccharide derived from citrus peels that has been shown to induce natural killer cell activity in myeloid leukemia cells and also act as a natural chelation agent to help excrete toxic metals from healthy human subjects. We hypothesized that MCP might have a counteracting effect against CdCl2 toxicity through cancer-related pathways. This study investigates the effects of MCP on CdCl2 toxicity in C. elegans, which shares a number of cancer-related pathways with mammals. The results indicated that MCP was able to significantly counter the toxic effects of CdCl2 on C. elegans lifespan and development. Our studies suggest that the beneficial effects of MCP may result from its ability to mitigate the effects of CdCl2 on gene expression, particularly in conserved pathways associated with apoptosis, tumor induction and suppression and inflammation-related pathways.

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来源期刊
CiteScore
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自引率
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审稿时长
61 days
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