修饰柑橘果胶对cdcl2处理的秀丽隐杆线虫的癌症相关通路具有预防作用

IF 4.6 Q1 CHEMISTRY, APPLIED Food Hydrocolloids for Health Pub Date : 2023-10-04 DOI:10.1016/j.fhfh.2023.100161
Denia Cai Shi , Arland T. Hotchkiss Jr , Michael A. Lawton , Rong Di
{"title":"修饰柑橘果胶对cdcl2处理的秀丽隐杆线虫的癌症相关通路具有预防作用","authors":"Denia Cai Shi ,&nbsp;Arland T. Hotchkiss Jr ,&nbsp;Michael A. Lawton ,&nbsp;Rong Di","doi":"10.1016/j.fhfh.2023.100161","DOIUrl":null,"url":null,"abstract":"<div><p>Cadmium chloride (CdCl<sub>2</sub>) is a toxic compound found as a pollutant in the environment due to agricultural and industrial sources. Exposure to Cd<sup>2+</sup> is known to promote malignant tumors such as lung cancer and leukemia. While the current medications for cadmium toxicity focus on treatments to promote the excretion from the body, treatments to improve health after cadmium exposure are less well studied. Modified citrus pectin (MCP) is a polysaccharide derived from citrus peels that has been shown to induce natural killer cell activity in myeloid leukemia cells and also act as a natural chelation agent to help excrete toxic metals from healthy human subjects. We hypothesized that MCP might have a counteracting effect against CdCl<sub>2</sub> toxicity through cancer-related pathways. This study investigates the effects of MCP on CdCl<sub>2</sub> toxicity in <em>C. elegans</em>, which shares a number of cancer-related pathways with mammals. The results indicated that MCP was able to significantly counter the toxic effects of CdCl<sub>2</sub> on <em>C. elegans</em> lifespan and development. Our studies suggest that the beneficial effects of MCP may result from its ability to mitigate the effects of CdCl<sub>2</sub> on gene expression, particularly in conserved pathways associated with apoptosis, tumor induction and suppression and inflammation-related pathways.</p></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Modified citrus pectin confers a preventative effect on cancer-related pathways in CdCl2-treated C. elegans\",\"authors\":\"Denia Cai Shi ,&nbsp;Arland T. Hotchkiss Jr ,&nbsp;Michael A. Lawton ,&nbsp;Rong Di\",\"doi\":\"10.1016/j.fhfh.2023.100161\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Cadmium chloride (CdCl<sub>2</sub>) is a toxic compound found as a pollutant in the environment due to agricultural and industrial sources. Exposure to Cd<sup>2+</sup> is known to promote malignant tumors such as lung cancer and leukemia. While the current medications for cadmium toxicity focus on treatments to promote the excretion from the body, treatments to improve health after cadmium exposure are less well studied. Modified citrus pectin (MCP) is a polysaccharide derived from citrus peels that has been shown to induce natural killer cell activity in myeloid leukemia cells and also act as a natural chelation agent to help excrete toxic metals from healthy human subjects. We hypothesized that MCP might have a counteracting effect against CdCl<sub>2</sub> toxicity through cancer-related pathways. This study investigates the effects of MCP on CdCl<sub>2</sub> toxicity in <em>C. elegans</em>, which shares a number of cancer-related pathways with mammals. The results indicated that MCP was able to significantly counter the toxic effects of CdCl<sub>2</sub> on <em>C. elegans</em> lifespan and development. Our studies suggest that the beneficial effects of MCP may result from its ability to mitigate the effects of CdCl<sub>2</sub> on gene expression, particularly in conserved pathways associated with apoptosis, tumor induction and suppression and inflammation-related pathways.</p></div>\",\"PeriodicalId\":12385,\"journal\":{\"name\":\"Food Hydrocolloids for Health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2023-10-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Hydrocolloids for Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667025923000456\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Hydrocolloids for Health","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667025923000456","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0

摘要

氯化镉(CdCl2)是一种有毒化合物,因农业和工业来源而在环境中被发现为污染物。已知暴露于Cd2+会促进恶性肿瘤,如肺癌和白血病。虽然目前治疗镉毒性的药物侧重于促进身体排泄的治疗方法,但对镉暴露后改善健康的治疗方法研究较少。改性柑橘果胶(MCP)是一种从柑橘皮中提取的多糖,已被证明可诱导髓系白血病细胞的自然杀伤细胞活性,也可作为天然螯合剂帮助健康人体排出有毒金属。我们假设MCP可能通过癌症相关途径对抗CdCl2的毒性。本研究调查了MCP对秀丽隐杆线虫CdCl2毒性的影响,秀丽隐杆虫与哺乳动物有许多癌症相关途径。结果表明,MCP能够显著对抗CdCl2对秀丽隐杆线虫寿命和发育的毒性作用。我们的研究表明,MCP的有益作用可能是由于其能够减轻CdCl2对基因表达的影响,特别是在与细胞凋亡、肿瘤诱导和抑制以及炎症相关的保守途径中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Modified citrus pectin confers a preventative effect on cancer-related pathways in CdCl2-treated C. elegans

Cadmium chloride (CdCl2) is a toxic compound found as a pollutant in the environment due to agricultural and industrial sources. Exposure to Cd2+ is known to promote malignant tumors such as lung cancer and leukemia. While the current medications for cadmium toxicity focus on treatments to promote the excretion from the body, treatments to improve health after cadmium exposure are less well studied. Modified citrus pectin (MCP) is a polysaccharide derived from citrus peels that has been shown to induce natural killer cell activity in myeloid leukemia cells and also act as a natural chelation agent to help excrete toxic metals from healthy human subjects. We hypothesized that MCP might have a counteracting effect against CdCl2 toxicity through cancer-related pathways. This study investigates the effects of MCP on CdCl2 toxicity in C. elegans, which shares a number of cancer-related pathways with mammals. The results indicated that MCP was able to significantly counter the toxic effects of CdCl2 on C. elegans lifespan and development. Our studies suggest that the beneficial effects of MCP may result from its ability to mitigate the effects of CdCl2 on gene expression, particularly in conserved pathways associated with apoptosis, tumor induction and suppression and inflammation-related pathways.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
4.50
自引率
0.00%
发文量
0
审稿时长
61 days
期刊最新文献
Green synthesis of silver nanoparticles from mulberry leaf through hot melt extrusion: Enhanced antioxidant, antibacterial, anti-inflammatory, antidiabetic, and anticancer properties Silkworm pupae protein-based film incorporated with Catharanthus roseus leaf extract-based nanoparticles enhanced the lipid stability and microbial quality of cheddar cheese Re-processing of pharmaceutical herb residues using isolated probiotics from plant sources and their beneficial effects on diarrhea Investigating next-generation edible packaging: Protein-based films and coatings for delivering active compounds Recent advances on antimicrobial peptide and polysaccharide hydrogels
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1