二氧化二胺/明胶体系的低温成型及其性能

IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY Moscow University Chemistry Bulletin Pub Date : 2023-03-25 DOI:10.3103/S0027131422070124

O. I. Vernaya, A. S. Shumilkin, D. L. Karlova, A. S. Shevchenko, A. A. Makeeva, A. V. Shabatin, A. M. Semenov, T. I. Shabatina, M. Ya. Melnikov

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引用次数: 0

摘要

用抗菌药物二氧化二胺进行明胶系统的低温成型。本研究考虑了体系的合成条件(前体溶液中明胶浓度)对其结构特性、抗菌活性和药物释放时间的影响。用扫描电镜、红外光谱和紫外光谱对二氧化二醇/明胶和二氧化二醇/水解胶原体系的组成和结构进行了表征。采用圆盘扩散法测定所得体系对大肠杆菌和金黄色葡萄球菌的抑菌活性。

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Cryoformation and Properties of Dioxidine/Gelatin Systems

Cryoforming of gelatin systems with the antibacterial drug dioxidine is carried out. The study considers the effect of systems’ synthesis conditions (gelatin concentration in the precursor solution) on their structural characteristics, antibacterial activity, and drug release time. The composition and structure of the dioxidine/gelatin and dioxidine/hydrolyzed collagen systems are characterized by SEM, IR, and UV spectroscopy. The disk diffusion method is used to determine the antibacterial activity of the obtained systems against E. coli and S. aureus.

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来源期刊

Moscow University Chemistry Bulletin CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

1.30

自引率

14.30%

发文量

期刊介绍： Moscow University Chemistry Bulletin is a journal that publishes review articles, original research articles, and short communications on various areas of basic and applied research in chemistry, including medical chemistry and pharmacology.