短期禁食影响健康男性和女性肌酸代谢的生物标志物

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM Human Nutrition and Metabolism Pub Date : 2023-08-30 DOI:10.1016/j.hnm.2023.200217

Marijana Ranisavljev , Nikola Todorovic , Jovana Panic , Bogdan Andjelic , Milan Vranes , Sergej M. Ostojic

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引用次数: 0

摘要

我们研究了24小时禁食对24名非素食健康成年人血清胍乙酸（GAA）、肌酸和肌酸酐水平的影响。在干预前后进行采血，并根据禁食引起的血浆容量变化对水平进行校正。禁食导致血清GAA显著降低39.5%（p＜0.001），而肌酸酐水平增加14.7%（p＜0.01）；肌酸的浓度保持不变。禁食期间GAA的减少可能表明这种能量需求条件下对肌酸生产的需求增加和/或潜在的肾功能障碍，这需要进一步探索。

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Short-term fasting affects biomarkers of creatine metabolism in healthy men and women

We studied the effects of 24-h fasting on serum levels of guanidinoacetic acid (GAA), creatine, and creatinine in 24 non-vegetarian healthy adults. Blood was taken before and following an intervention, with levels corrected for fasting-induced changes in plasma volume. Food abstention induced a significant decrease in serum GAA by 39.5% (p < 0.001), while creatinine levels increased by 14.7% (p < 0.01); the concentration of creatine remains unchanged. The reduction in GAA during fasting may indicate an increased demand for creatine production for this energy-demanding condition and/or potential kidney dysfunction which requires further exploration.

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